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Gene

rest

ID
ZDB-GENE-080415-1
Name
RE1-silencing transcription factor
Symbol
rest Nomenclature History
Previous Names
  • Nrsf (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of neuron maturation; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rest Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 27 Alliance ?Deafness, autosomal dominant 27 612431
gingival fibromatosis 5 Alliance Fibromatosis, gingival, 5 617626
{Wilms tumor 6, susceptibility to} 616806
Associated With rest Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:G9BN94 854
UniProtKB:Q2EI20 855
UniProtKB:A0A0R4IKA2 854
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rest polyclonal Rabbit
  • IHC
Abcam plc
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations