ZFIN ID: ZDB-GENE-080415-1
Gene Name: RE1-silencing transcription factor
Gene Symbol: rest    Nomenclature History

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Previous Name: Nrsf (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including locomotory behavior; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Is expressed in ectoderm; endoderm; fin; head mesenchyme; and nervous system. Orthologous to human REST (RE1 silencing transcription factor).
Genome Resources: Alliance (1),  Gene:564772 (1),  Ensembl(GRCz11):ENSDARG00000103046 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35769 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sbu29 Small Deletion Exon 1 Frameshift ZINC_FINGER_NUCLEASE
    sbu34 Insertion Exon 1 Frameshift ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rest N/A 5
    MO2-rest N/A 2
    MO3-rest N/A 1
    MO4-rest N/A 1
    MO5-rest N/A 1
    DISEASE ASSOCIATED WITH rest HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 27 Alliance ?Deafness, autosomal dominant 27 612431
    gingival fibromatosis 5 Alliance Fibromatosis, gingival, 5 617626
    {Wilms tumor 6, susceptibility to} 616806
    DISEASE ASSOCIATED WITH rest VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process facial nucleus development (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rest-201 (1)    Ensembl 6301
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-rest polyclonal Rabbit IHC Abcam plc
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rest No data available
    MARKER RELATIONSHIPS
    rest Contained in: [BAC] CH211-273E20
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039820 (1)
    Genomic GenBank:AL954718 (1) 163689 nt
    Select Tool
    Polypeptide UniProtKB:Q2EI20 (1) 855 aa
    Sequence Information (all 15)
    ORTHOLOGY for rest ( Chr: 14 )
    CITATIONS (35)