header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080320-1
Gene Name: nemo-like kinase, type 2
Gene Symbol: nlk2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: nlka

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and MAP kinase activity. Involved in midbrain development; peptidyl-threonine phosphorylation; and positive regulation of Wnt signaling pathway. Predicted to localize to the cytoplasm and nucleus. Is expressed in head and midbrain. Orthologous to human NLK (nemo like kinase).
Genome Resources: Alliance (1),  Gene:563460 (1),  Ensembl(GRCz11):ENSDARG00000028793 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Ota et al., 2012
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-15 (30.0h-36.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16109 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24989 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nlk2 N/A 1
    MO2-nlk2 N/A 1
    DISEASE ASSOCIATED WITH nlk2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nlk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process peptidyl-threonine phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nlk2-202 (1)    Ensembl 3511
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nlk polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nlk2 No data available
    MARKER RELATIONSHIPS
    nlk2 Contained in: [BAC] CH211-285L4 (order this), DKEY-9M4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113485 (1) 1615 bp
    Genomic GenBank:BX649531 (1) 185865 bp
    Select Tool
    Polypeptide UniProtKB:E7F1L8 (1) 533 aa
    Sequence Clusters UniGene:143303 (1)
    Sequence Information (all 14)
    ORTHOLOGY for nlk2 ( Chr: 15 )
    CITATIONS (18)