ZFIN ID: ZDB-GENE-080320-1
Gene Name: nemo-like kinase, type 2
Gene Symbol: nlk2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have MAP kinase activity. Involved in midbrain development; peptidyl-threonine phosphorylation; and positive regulation of Wnt signaling pathway. Predicted to localize to cytoplasm and nucleus. Is expressed in head and midbrain. Orthologous to human NLK (nemo like kinase).
Genome Resources: Alliance (1),  Gene:563460 (1),  Ensembl(GRCz11):ENSDARG00000028793 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Ota et al., 2012
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-15 (30.0h-36.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16109 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24989 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nlk2 N/A 1
    MO2-nlk2 N/A 1
    DISEASE ASSOCIATED WITH nlk2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nlk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process peptidyl-threonine phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nlk2-202 (1)    Ensembl 3511
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nlk polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nlk2 No data available
    MARKER RELATIONSHIPS
    nlk2 Contained in: [BAC] CH211-285L4, DKEY-9M4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001113485 (1) 1615 nt
    Genomic GenBank:BX649531 (1) 185865 nt
    Select Tool
    Polypeptide UniProtKB:E7F1L8 (1) 533 aa
    Sequence Information (all 13)
    ORTHOLOGY for nlk2 ( Chr: 15 )
    CITATIONS (19)