ZFIN ID: ZDB-GENE-080220-48
Gene Name: integrin, alpha 8
Gene Symbol: itga8    Nomenclature History

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Previous Name: zgc:172265

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in cilium assembly and embryonic viscerocranium morphogenesis. Predicted to localize to the integrin complex. Human ortholog(s) of this gene implicated in end stage renal failure; ovarian cancer; renal agenesis; and schizophrenia. Is expressed in hair cell; head; inner ear; neuromast hair cell; and pharyngeal arch. Orthologous to human ITGA8 (integrin subunit alpha 8).
Genome Resources: Alliance (1),  Gene:100141346 (1),  Ensembl(GRCz11):ENSDARG00000078717 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1161 Indel Unknown Unknown ENU
oz6 Small Deletion Unknown Frameshift, Premature Stop CRISPR
oz7 Small Deletion Unknown Frameshift CRISPR
sa2856 Point Mutation Unknown Splice Site ENU
sa6436 Point Mutation Unknown Premature Stop ENU
sa9052 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14004 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15736 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17254 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22861 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22862 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42737 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itga8 1
    MO1-itga8 N/A 1
    MO2-itga8 N/A 1
    DISEASE ASSOCIATED WITH itga8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    renal agenesis Alliance Renal hypodysplasia/aplasia 1 191830
    DISEASE ASSOCIATED WITH itga8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000413 Integrin alpha chain
    Repeat IPR013517 FG-GAP repeat
    Repeat IPR013519 Integrin alpha beta-propellor
    Domain IPR013649 Integrin alpha-2
    Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    Homologous_superfamily IPR028994 Integrin alpha, N-terminal
    Homologous_superfamily IPR032695 Integrin domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itga8-202 (1)    Ensembl 1656
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga8 No data available
    MARKER RELATIONSHIPS
    itga8 Contained in: [BAC] DKEY-69C5 (1) (order this), DKEY-261N13 (1) (order this)
    itga8 Encodes: [cDNA] MGC:172265 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114911 (1) 2445 bp
    Genomic GenBank:BX072564 (1) 205057 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A023GU64 (1) 1059 aa
    Sequence Information (all 20)
    ORTHOLOGY for itga8 ( Chr: 16 )
    CITATIONS (21)