ZFIN is now using GRCz12tu for Genomic Data

Gene

focad

ID

ZDB-GENE-080213-1

Name

focadhesin

Symbol

focad Nomenclature History

Previous Names

gb:ct717615

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in regulation of post-transcriptional gene silencing. Predicted to be located in cytosol and focal adhesion. Is expressed in male organism. Used to study liver cirrhosis. Human ortholog(s) of this gene implicated in liver disease. Orthologous to human FOCAD (focadhesin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Moreno Traspas et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Moreno Traspas et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With focad Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Liver disease, severe congenital	619991

Associated With focad Via Experimental Models

Human Disease	Fish	Conditions	Citations
liver cirrhosis	focad^imb6/imb6 (AB)	standard conditions	Moreno Traspas et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021392	Focadhesin, C-terminal domain
Domain	IPR022542	Focadhesin/RST, DUF3730
Family	IPR045163	Focadhesin/RST1
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3AU35	InterPro	1806
UniProtKB:A0AB13A9W3	InterPro	1806
UniProtKB:E7FGT5	InterPro	1806
UniProtKB:A0AC58FX36	InterPro	1794

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	focad-201 (1) Ensembl	Ensembl		5,811 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000063356 (1) Ensembl	Ensembl		544 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-focad	polyclonal	focad		Rabbit	WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance

Citations