ZFIN ID: ZDB-GENE-080204-52
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Gene Symbol: abcb4    Nomenclature History

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Previous Names: abcb1b (1), zgc:172149

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits ATPase-coupled protein transmembrane transporter activity; efflux transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in response to toxic substance. Predicted to localize to integral component of membrane. Is expressed in digestive system and head. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cholestasis (multiple); inflammatory bowel disease (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB4 (ATP binding cassette subfamily B member 4).
Genome Resources: Alliance (1),  Gene:100136865 (1),  Ensembl(GRCz11):ENSDARG00000010936 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9671 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16234 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25016 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-abcb4 N/A 1
    MO2-abcb4 N/A 1
    DISEASE ASSOCIATED WITH abcb4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cholecystitis Alliance Gallbladder disease 1 600803
    inflammatory bowel disease 13 Alliance {Inflammatory bowel disease 13} 612244
    intrahepatic cholestasis of pregnancy 3 Alliance Cholestasis, intrahepatic, of pregnancy, 3 614972
    progressive familial intrahepatic cholestasis 3 Alliance Cholestasis, progressive familial intrahepatic 3 602347
    {Colchicine resistance} 120080
    DISEASE ASSOCIATED WITH abcb4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to toxic substance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase-coupled protein transmembrane transporter activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abcb4-201 (1)    Ensembl 4032
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-abcb4 Mouse IHC Santa Cruz Biotechnology, Inc.
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcb4 No data available
    MARKER RELATIONSHIPS
    abcb4 Contained in: [BAC] CH211-215G1 (1), DKEY-24I24 (1) (order this)
    abcb4 Encodes: [cDNA] MGC:172149 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114583 (1) 2160 nt
    Genomic GenBank:BX322614 (1) 199783 nt
    Select Tool
    Polypeptide UniProtKB:E7F1E3 (1) 1275 aa
    Sequence Information (all 19)
    ORTHOLOGY for abcb4 ( Chr: 16 )
    CITATIONS (46)