Gene

abcb4

ID
ZDB-GENE-080204-52
Name
ATP-binding cassette, sub-family B (MDR/TAP), member 4
Symbol
abcb4 Nomenclature History
Previous Names
  • abcb1b (1)
  • zgc:172149
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Exhibits ATPase-coupled protein transmembrane transporter activity; efflux transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in response to toxic substance. Predicted to localize to integral component of membrane. Is expressed in digestive system and head. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cholestasis (multiple); inflammatory bowel disease (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB4 (ATP binding cassette subfamily B member 4).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Fischer et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcb4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cholecystitis Alliance Gallbladder disease 1 600803
inflammatory bowel disease 13 Alliance {Inflammatory bowel disease 13} 612244
intrahepatic cholestasis of pregnancy 3 Alliance Cholestasis, intrahepatic, of pregnancy, 3 614972
progressive familial intrahepatic cholestasis 3 Alliance Cholestasis, progressive familial intrahepatic 3 602347
{Colchicine resistance} 120080
Associated With abcb4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Family IPR030275 Multidrug resistance protein 3
Family IPR039421 Type I protein exporter
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter, conserved site ABC transporter-like ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily Multidrug resistance protein 3 P-loop containing nucleoside triphosphate hydrolase Type I protein exporter
UniProtKB:A8WG28 650
UniProtKB:E7F1E3 1275
UniProtKB:K9M7F0 1275
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-abcb4 Mouse
  • IHC
Santa Cruz Biotechnology, Inc.
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations