ZFIN ID: ZDB-GENE-080204-52
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Gene Symbol: abcb4
Previous Names: abcb1b (1), zgc:172149
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
  head, intestinal bulb, intestine, liver (all 5) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9671 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16234 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-abcb4 (1), MO2-abcb4 (1)
    PHENOTYPE
    Data: 2 figures from Fischer et al., 2013
    Observed in: efflux transmembrane transporter activity
    DISEASE ASSOCIATED WITH abcb4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cholecystitis Gallbladder disease 1 600803
    inflammatory bowel disease {Inflammatory bowel disease 13} 612244
    intrahepatic cholestasis Cholestasis, intrahepatic, of pregnancy, 3 614972
    Cholestasis, progressive familial intrahepatic 3 602347
    {Colchicine resistance} 120080
    {Colchicine resistance} 120080
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to toxic substance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein-transmembrane transporting ATPase activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA abcb4-001 (1) 4032
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM abcb4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    abcb4Contained in: [BAC] CH211-215G1 (1) (order this), DKEY-24I24 (1) (order this)
    abcb4Encodes: [cDNA] MGC:172149 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001316714 (1) 4535bp
    Genomic GenBank:BX322614 (1) 199783bp
    Select Tool
    Polypeptide UniProtKB:E7F1E3 (1) 1275aa
    Sequence Clusters UniGene:110810 (1)
    Sequence Information (all 22)
    OTHER abcb4 GENE PAGES
  • Gene:100136865 (1)
  • VEGA:OTTDARG00000034201 (1)
  • Ensembl(GRCz10):ENSDARG00000010936 (1)
  • ORTHOLOGY for abcb4 (Chr: 16)
    Species Symbol Chromosome Accession # Evidence
    Human ABCB1 7
  • Gene:5243
  • OMIM:171050
  • HGNC:40
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Human ABCB4 7
  • Gene:5244
  • OMIM:171060
  • HGNC:45
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (3)
    Mouse Abcb1a 5
  • MGI:97570
  • Gene:18671
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Abcb1b 5
  • MGI:97568
  • Gene:18669
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Abcb4 5
  • MGI:97569
  • Gene:18670
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (25)