Gene
abcb4
- ID
- ZDB-GENE-080204-52
- Name
- ATP-binding cassette, sub-family B (MDR/TAP), member 4
- Symbol
- abcb4 Nomenclature History
- Previous Names
-
- abcb1b (1)
- zgc:172149
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Exhibits ATPase-coupled protein transmembrane transporter activity; efflux transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in response to toxic substance. Predicted to localize to integral component of membrane. Is expressed in digestive system and head. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cholestasis (multiple); inflammatory bowel disease (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB4 (ATP binding cassette subfamily B member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Fischer et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017871 | ABC transporter-like, conserved site |
Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
Family | IPR039421 | Type 1 protein exporter |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
---|---|---|---|---|---|---|---|---|
UniProtKB:E7F1E3
|
1275 | |||||||
UniProtKB:A0A8N1TR42
|
650 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-abcb4 | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available