Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080204-52
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Gene Symbol: abcb4
Previous Names: abcb1b (1), zgc:172149
Location: Chr: 16   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from Fischer et al., 2013
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  intestinal bulb, intestine, whole organism
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa16234, sa9671
Knockdown reagents: MO1-abcb4 (1), MO2-abcb4 (1)
PHENOTYPE
Data: 2 figures from Fischer et al., 2013
Observed in: efflux transmembrane transporter activity

Phenotype of Human Orthologue OMIM Phenotype ID
Cholestasis, intrahepatic, of pregnancy, 3 614972
Cholestasis, progressive familial intrahepatic 3 602347
Gallbladder disease 1 600803
GENE ONTOLOGY
Ontology GO Term
Biological Process transmembrane transport (more)
Cellular Component integral component of membrane (more)
Molecular Function efflux transmembrane transporter activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001140 (1)
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA abcb4-001 (1) 4032
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcb4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    abcb4 Contained in: [BAC] CH211-215G1 (1) (order this), DKEY-24I24 (1)
    abcb4 Encodes: [cDNA] MGC:172149 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114583 (1) 2160 bp
    Genomic GenBank:BX322614 (1) 199783 bp
    Select Tool
    Polypeptide UniProtKB:E7F1E3 (1) 1275 aa
    Sequence Clusters UniGene:110810 (1)
    Sequence Information (all 17)
    OTHER abcb4 GENE PAGES
  • Gene:100136865 (1)
  • VEGA:OTTDARG00000034201 (1)
  • Ensembl(Zv9):ENSDARG00000010936 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish abcb4 16  
    Human ABCB4 7 (7q21.1)
  • OMIM:171060
  • Gene:5244
  • Mouse Abcb4 5 ( 3.43 cM)
  • MGI:97569
  • Gene:18670
  • Orthology Details
    CITATIONS (18)