ZFIN ID: ZDB-GENE-080204-52
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Gene Symbol: abcb4
Previous Names: abcb1b (1), zgc:172149
Location: Chr: 16   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
  head, intestinal bulb, intestine, liver (all 5) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-abcb4 (1), MO2-abcb4 (1)

Allele Type Mutagen Suppliers
sa9671 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16234 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 2 figures from Fischer et al., 2013
    Observed in: efflux transmembrane transporter activity
    DISEASE ASSOCIATED WITH abcb4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    intrahepatic cholestasis Cholestasis, intrahepatic, of pregnancy, 3 614972
    Cholestasis, progressive familial intrahepatic 3 602347
    cholecystitis Gallbladder disease 1 600803
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to toxic substance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein-transmembrane transporting ATPase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR030275 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA abcb4-001 (1) 4032
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcb4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    abcb4 Contained in: [BAC] CH211-215G1 (1) (order this), DKEY-24I24 (1) (order this)
    abcb4 Encodes: [cDNA] MGC:172149 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114583 (1) 2160 bp
    Genomic GenBank:BX322614 (1) 199783 bp
    Select Tool
    Polypeptide UniProtKB:E7F1E3 (1) 1275 aa
    Sequence Clusters UniGene:110810 (1)
    Sequence Information (all 17)
    OTHER abcb4 GENE PAGES
  • Gene:100136865 (1)
  • VEGA:OTTDARG00000034201 (1)
  • Ensembl(Zv9):ENSDARG00000010936 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish abcb4 16  
    Human ABCB4 7 (7q21.1)
  • OMIM:171060
  • Gene:5244
  • Mouse Abcb4 5 ( 3.43 cM)
  • MGI:97569
  • Gene:18670
  • Orthology Details
    CITATIONS (20)