Gene

lifrb

ID
ZDB-GENE-080107-2
Name
LIF receptor subunit alpha b
Symbol
lifrb Nomenclature History
Previous Names
  • si:dkey-120e24.3
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including immune system; liver; nervous system; notochord; and otic vesicle. Human ortholog(s) of this gene implicated in osteochondrodysplasia and primary cutaneous amyloidosis. Orthologous to several human genes including LIFR (LIF receptor subunit alpha).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 5 from Hanington et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lifrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome 601559
Associated With lifrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Domain IPR003961 Fibronectin type III
Domain IPR040817 Leukemia inhibitory factor receptor, D2 domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Leukemia inhibitory factor receptor, D2 domain Long hematopoietin receptor, Gp130 family 2, conserved site
UniProtKB:A8WH83 956
UniProtKB:A0A2R8QN64 956
UniProtKB:F1QRJ3 951
UniProtKB:F1Q5F5 960
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations