Gene

lepr

ID

ZDB-GENE-080104-1

Name

leptin receptor

Symbol

lepr Nomenclature History

Previous Names

obr (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have cytokine binding activity and cytokine receptor activity. Involved in several processes, including response to glucose; sensory organ development; and type B pancreatic cell development. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and osteoporosis. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Orthologous to human LEPR (leptin receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 22 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lepr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Obesity, morbid, due to leptin receptor deficiency	614963

Associated With lepr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Domain	IPR010457	Immunoglobulin C2-set-like, ligand-binding
Domain	IPR041182	Leptin receptor, immunoglobulin-like domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily