ZFIN ID: ZDB-GENE-080104-1
Gene Name: leptin receptor
Gene Symbol: lepr    Nomenclature History

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Previous Name: obr (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cytokine binding activity and cytokine receptor activity. Involved in several processes, including response to glucose; sensory organ development; and type B pancreatic cell development. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including digestive system; musculature system; nervous system; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and osteoporosis. Orthologous to human LEPR (leptin receptor).
Genome Resources: Alliance (1),  Gene:567241 (1),  Ensembl(GRCz11):ENSDARG00000070961 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb251 Indel Exon 8 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb252 Small Deletion Exon 8 Unknown CRISPR
    la025495Tg Transgenic Insertion Unknown Unknown DNA
    sa323 Point Mutation Unknown Premature Stop ENU
    sa1508 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5372 Point Mutation Unknown Premature Stop ENU
    sa12953 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38556 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf3068 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lepr 1
    CRISPR2-lepr
    1
    CRISPR3-lepr
    2
    CRISPR4-lepr 1
    MO1-lepr N/A 2
    MO2-lepr N/A 1
    DISEASE ASSOCIATED WITH lepr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Obesity, morbid, due to leptin receptor deficiency 614963
    DISEASE ASSOCIATED WITH lepr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function leptin receptor activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lepr-201 (1)    Ensembl 5772
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-lepr polyclonal IgG Goat IHC, WB Santa Cruz Biotechnology, Inc.
    2
    Ab1-lepr polyclonal IgG Goat IHC, WB Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lepr
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(lepr:lepr-mCherry) lepr leprmCherry Danio rerio 1 2
    MARKER RELATIONSHIPS
    lepr Contained in: [BAC] CH211-157E20, DKEY-1K24 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001113376 (1) 3342 nt
    Genomic GenBank:BX936440 (1) 197744 nt
    Select Tool
    Polypeptide UniProtKB:A8WH80 (1) 1091 aa
    Sequence Information (all 21)
    ORTHOLOGY for lepr ( Chr: 6 )
    CITATIONS (57)