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ZIRC
ZFIN ID: ZDB-GENE-080103-2
Gene Name: prolactin receptor a
Gene Symbol: prlra    Nomenclature History

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Previous Name: wu:fj65c07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have cytokine binding activity; peptide hormone binding activity; and prolactin receptor activity. Predicted to be involved in prolactin signaling pathway. Predicted to localize to the external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hyperprolactinemia. Is expressed in gill; hypophysis; pancreatic bud; pronephric duct; and pronephros. Orthologous to human PRLR (prolactin receptor).
Genome Resources: Alliance (1),  Gene:407651 (1),  Ensembl(GRCz11):ENSDARG00000016570 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43590 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44958 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prlra N/A 1
    PHENOTYPE
    Data: Fig. 4 from Liu et al., 2006
    Observed in:
    DISEASE ASSOCIATED WITH prlra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hyperprolactinemia 615555
    Multiple fibroadenomas of the breast 615554
    DISEASE ASSOCIATED WITH prlra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process prolactin signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine receptor activity (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prlra-201 (1)    Ensembl 6237
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prlra No data available
    MARKER RELATIONSHIPS
    prlra Contained in: [BAC] CH211-213L7 (1) (order this), DKEY-264M23 (order this)
    prlra Encodes: [EST] fj65c07
    [cDNA] MGC:194467 (1) (order this), MGC:194475 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128677 (1)
    Genomic GenBank:CR318662 (1) 200648 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QG81 (1) 606 aa
    Sequence Clusters UniGene:80289 (1)
    Sequence Information (all 29)
    ORTHOLOGY for prlra ( Chr: 21 )
    CITATIONS (28)