Gene

chata

ID
ZDB-GENE-080102-2
Name
choline O-acetyltransferase a
Symbol
chata Nomenclature History
Previous Names
  • baj
  • chat
  • unm tk64
  • unm_tk64
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to localize to cytoplasm and neuron projection. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Is expressed in brain; neurons; post-vent region; and spinal cord. Orthologous to human CHAT (choline O-acetyltransferase).
Genome Resources
Note
Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.
Comparative Information
Expression
All Expression Data
20 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chata Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myasthenic syndrome 6 Alliance Myasthenic syndrome, congenital, 6, presynaptic 254210
Associated With chata Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR039551 Choline/carnitine acyltransferase domain
Family IPR000542 Acyltransferase ChoActase/COT/CPT
Homologous_superfamily IPR042231 Choline/Carnitine o-acyltransferase, domain 2
Homologous_superfamily IPR042232 Choline/Carnitine o-acyltransferase, domain 1
Domain Details Per Protein
Protein Length Acyltransferase ChoActase/COT/CPT Choline/carnitine acyltransferase domain Choline/Carnitine o-acyltransferase, domain 1 Choline/Carnitine o-acyltransferase, domain 2
UniProtKB:B2ZGJ1 637
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-chat polyclonal Goat
  • IHC
Millipore
45
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations