ZFIN ID: ZDB-GENE-080102-2
Gene Name: choline O-acetyltransferase a
Gene Symbol: chata    Nomenclature History

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Previous Names: baj, chat, unm tk64, unm_tk64

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to localize to cytoplasm and neuron projection. Is expressed in brain; neurons; post-vent region; and spinal cord. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).
Genome Resources: Alliance (1),  Gene:100170938 (1),  Ensembl(GRCz11):ENSDARG00000015854 (2)
Note: Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22323 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45487 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tf247 Point Mutation Acceptor Splice Site of Intron 2 Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tk64 Point Mutation Exon 3 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chata N/A 1
    MO2-chata N/A 2
    DISEASE ASSOCIATED WITH chata HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 6 Alliance Myasthenic syndrome, congenital, 6, presynaptic 254210
    DISEASE ASSOCIATED WITH chata VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    congenital myasthenic syndrome chatatk64/tk64(AB) standard conditions Joshi et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process locomotory behavior (more)
    Cellular Component cytoplasm (more)
    Molecular Function choline O-acetyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chata-202 (1)    Ensembl 2105
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-chat polyclonal Goat IHC Millipore
    44
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chata
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(chata:gfp-gal4ff) chata GAL4FFGFP Danio rerio 1 1
    TgBAC(chata:GAL4-VP16) chata GAL4VP16 Danio rerio 2 3
    MARKER RELATIONSHIPS
    chata Contained in: [BAC] CH211-222I16, CH211-232K3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001130719 (1) 1914 nt
    Genomic GenBank:BX855592 (1) 159646 nt
    Select Tool
    Polypeptide UniProtKB:B2ZGJ1 (1) 637 aa
    Sequence Information (all 17)
    ORTHOLOGY for chata ( Chr: 13 )
    CITATIONS (52)