Gene

chata

ID
ZDB-GENE-080102-2
Name
choline O-acetyltransferase a
Symbol
chata Nomenclature History
Previous Names
  • baj
  • chat
  • unm tk64
  • unm_tk64
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to be active in cytoplasm and neuron projection. Is expressed in brain; neurons; post-vent region; and spinal cord. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Orthologous to human CHAT (choline O-acetyltransferase).
Genome Resources
Note
Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.
Comparative Information
Expression
All Expression Data
20 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chata Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myasthenic syndrome 6 Alliance Myasthenic syndrome, congenital, 6, presynaptic 254210
Associated With chata Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR039551 Choline/carnitine acyltransferase domain
Family IPR000542 Acyltransferase ChoActase/COT/CPT
Homologous_superfamily IPR042231 Choline/Carnitine o-acyltransferase, domain 2
Homologous_superfamily IPR042232 Choline/Carnitine o-acyltransferase, domain 1
Domain Details Per Protein
Protein Length Acyltransferase ChoActase/COT/CPT Choline/carnitine acyltransferase domain Choline/Carnitine o-acyltransferase, domain 1 Choline/Carnitine o-acyltransferase, domain 2
UniProtKB:B2ZGJ1 637
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-chat polyclonal Goat
  • IHC
Millipore
45
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations