ZFIN ID: ZDB-GENE-071130-1
Gene Name: NKD inhibitor of WNT signaling pathway 2a
Gene Symbol: nkd2a    Nomenclature History

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Previous Name: nkd2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including Kupffer's vesicle development; Spemann organizer formation; and negative regulation of canonical Wnt signaling pathway. Predicted to localize to cytoplasm. Is expressed in blastoderm; blastodisc; brain; and tail bud. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000055271 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nkd2a N/A 2
MO2-nkd2a N/A 3
MO3-nkd2a N/A 2
PHENOTYPE
Data: 2 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH nkd2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH nkd2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of canonical Wnt signaling pathway (more)
Cellular Component cytoplasm (more)
Molecular Function calcium ion binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nkd2a-201 (1)    Ensembl 1432
Browsers: EnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-nkd2a polyclonal Rabbit 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nkd2a No data available
MARKER RELATIONSHIPS
nkd2a Contained in: [BAC] CH73-377N8 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA GenBank:EF192161 (1) 1340 nt
Genomic GenBank:CU463028 (1) 114212 nt
Select Tool
Polypeptide UniProtKB:A4ZNR4 (1) 409 aa
Sequence Information (all 4)
ORTHOLOGY for nkd2a ( Chr: 16 )
CITATIONS (25)