ZFIN ID: ZDB-GENE-071001-1
Gene Name: ryanodine receptor 2a (cardiac)
Gene Symbol: ryr2a    Nomenclature History

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Previous Names: ryrba (1), pc7 (1), zmp:0000001097

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have calcium channel activity. Involved in smoothened signaling pathway. Is expressed in brain; cardiac muscle; spinal cord; and trigeminal ganglion. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2).
Genome Resources: Alliance (1),  Gene:100126126 (1),  Ensembl(GRCz11):ENSDARG00000098856 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22177 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38909 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z44 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-ryr2a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ryr2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 2 Alliance Arrhythmogenic right ventricular dysplasia 2 600996
    catecholaminergic polymorphic ventricular tachycardia 1 Alliance Ventricular tachycardia, catecholaminergic polymorphic, 1 604772
    DISEASE ASSOCIATED WITH ryr2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function calcium ion binding (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ryr2a No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021480192 (1)
    Genomic GenBank:CABZ01084956 (1) 30758 nt
    Select Tool
    Polypeptide UniProtKB:A7M794 (1) 277 aa
    Sequence Information (all 24)
    ORTHOLOGY for ryr2a ( Chr: 12 )
    CITATIONS (28)