Gene

lars2

ID
ZDB-GENE-070928-3
Name
leucyl-tRNA synthetase 2, mitochondrial
Symbol
lars2 Nomenclature History
Previous Names
  • zgc:165522
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Zhang et al., 2018
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Perrault syndrome Alliance Perrault syndrome 4 615300
Hydrops, lactic acidosis, and sideroblastic anemia 617021
Associated With lars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR002300 Aminoacyl-tRNA synthetase, class Ia
Domain IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain IPR025709 Leucyl-tRNA synthetase, editing domain
Family IPR002302 Leucine-tRNA ligase
Homologous_superfamily IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Leucine-tRNA ligase Leucyl-tRNA synthetase, editing domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding Rossmann-like alpha/beta/alpha sandwich fold Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
UniProtKB:F8W359 248
UniProtKB:A7MBM0 891
UniProtKB:F1R7M6 835
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations