ZFIN ID: ZDB-GENE-070912-83
Gene Name: DEAD (Asp-Glu-Ala-Asp) box helicase 6
Gene Symbol: ddx6    Nomenclature History

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Previous Names: p54a (1), si:ch211-147p17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have RNA helicase activity and mRNA binding activity. Involved in response to heat and stress granule assembly. Localizes to cytoplasmic ribonucleoprotein granule. Orthologous to human DDX6 (DEAD-box helicase 6).
Genome Resources: Alliance (1),  Gene:564633 (1),  Ensembl(GRCz11):ENSDARG00000061338 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16927 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17615 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23370 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36717 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ddx6 N/A 1
    DISEASE ASSOCIATED WITH ddx6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder with impaired language and dysmorphic facies 618653
    DISEASE ASSOCIATED WITH ddx6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to heat (more)
    Cellular Component cytoplasmic ribonucleoprotein granule (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddx6-201 (1)    Ensembl 5615
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-p54 Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddx6 No data available
    MARKER RELATIONSHIPS
    ddx6 Contained in: [BAC] CH211-147P17 (1)
    ddx6 Encodes: [EST] wz12416 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_679831 (1) 5706 nt
    Genomic GenBank:CR759774 (1) 149156 nt
    Select Tool
    Polypeptide UniProtKB:E7FD91 (1) 484 aa
    Sequence Information (all 14)
    ORTHOLOGY for ddx6 ( Chr: 18 )
    CITATIONS (19)