Gene

kcnh2a

ID
ZDB-GENE-070912-699
Name
potassium voltage-gated channel, subfamily H (eag-related), member 2a
Symbol
kcnh2a Nomenclature History
Previous Names
  • kcnh2
  • kcnh2l
  • si:dkeyp-99c4.6
  • zerg-2 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including digestive system; gill; heart; immune system; and muscle. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Leong et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnh2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
long QT syndrome 2 Alliance Long QT syndrome 2 613688
long QT syndrome 2 Alliance {Long QT syndrome 2, acquired, susceptibility to} 613688
short QT syndrome Alliance Short QT syndrome 1 609620
Associated With kcnh2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR005821 Ion transport domain
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Family IPR003967 Potassium channel, voltage-dependent, ERG
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Homologous_superfamily IPR035965 PAS domain superfamily
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain PAS domain PAS domain superfamily Potassium channel, voltage-dependent, EAG/ELK/ERG Potassium channel, voltage-dependent, ERG RmlC-like jelly roll fold Voltage-dependent channel domain superfamily
UniProtKB:A0A2R8Q5N6 1127
UniProtKB:B0V138 1253
UniProtKB:D9IW08 1127
UniProtKB:Q108P2 1253
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations