ZFIN ID: ZDB-GENE-070912-533
Gene Name: target of EGR1, exonuclease
Gene Symbol: toe1
Sequence Ontology ID : SO:0000704

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Previous Name: si:dkey-40i22.3

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have 3'-5'-exoribonuclease activity and snRNA binding activity; involved in brain development and neuron cellular homeostasis; predicted to localize to the Cajal body and cytoplasm; used  ...
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9914 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from Lardelli et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH toe1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 7 Pontocerebellar hypoplasia, type 7 614969
    DISEASE ASSOCIATED WITH toe1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    pontocerebellar hypoplasia AB/TU + MO2-toe1 standard conditions Lardelli et al., 2017
    AB/TU + MO1-toe1 standard conditions Lardelli et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000571 (1)
  • InterPro:IPR006941 (1)
  • InterPro:IPR012337 (1)
  • InterPro:IPR036397 (1)
  • InterPro:IPR036855 (1)
  • PROSITE:PS50103 (1)
  • Pfam:PF04857 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA toe1-002 (1) 803
    mRNA toe1-201 (1) 1830
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM toe1 No data available
    MARKER RELATIONSHIPS
    toe1Contained in: [BAC] CH73-382F3 (1) (order this), DKEY-40I22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001256682 (1)
    Genomic GenBank:BX649522 (1) 155396bp
    Select Tool
    Polypeptide UniProtKB:B8A5U4 (1) 483aa
    Sequence Clusters UniGene:83787 (1)
    Sequence Information (all 7)
    OTHER toe1 GENE PAGES
  • Alliance (1)
  • Gene:568260 (1)
  • VEGA:OTTDARG00000024952 (1)
  • Ensembl(GRCz11):ENSDARG00000077544 (2)
  • ORTHOLOGY for toe1 (Chr: 2)
    CITATIONS (13)