ZFIN ID: ZDB-GENE-070912-533
Gene Name: target of EGR1, exonuclease
Gene Symbol: toe1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkey-40i22.3

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have 3'-5'-exoribonuclease activity and snRNA binding activity. Involved in brain development and neuron cellular homeostasis. Predicted to localize to the Cajal body and cytoplasm. Used to study pontocerebellar hypoplasia. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease).
Genome Resources: Alliance (1),  Gene:568260 (1),  Ensembl(GRCz11):ENSDARG00000077544 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9914 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9935 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-toe1 N/A 1
    MO2-toe1 N/A 1
    DISEASE ASSOCIATED WITH toe1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 7 Alliance Pontocerebellar hypoplasia, type 7 614969
    DISEASE ASSOCIATED WITH toe1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    pontocerebellar hypoplasia AB/TU + MO2-toe1 standard conditions Lardelli et al., 2017
    AB/TU + MO1-toe1 standard conditions Lardelli et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component Cajal body (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000571 Zinc finger, CCCH-type
    Family IPR006941 Ribonuclease CAF1
    Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
    Homologous_superfamily IPR036397 Ribonuclease H superfamily
    Homologous_superfamily IPR036855 Zinc finger, CCCH-type superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA toe1-201 (1)    Ensembl 1830
    ncRNA toe1-002 (1)    Ensembl 803
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM toe1 No data available
    MARKER RELATIONSHIPS
    toe1 Contained in: [BAC] CH73-382F3 (1), DKEY-40I22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001256682 (1)
    Genomic GenBank:BX649522 (1) 155396 bp
    Select Tool
    Polypeptide UniProtKB:B8A5U4 (1) 483 aa
    Sequence Information (all 6)
    ORTHOLOGY for toe1 ( Chr: 2 )
    CITATIONS (15)