Gene

pappa2

ID
ZDB-GENE-070912-525
Name
pappalysin 2
Symbol
pappa2 Nomenclature History
Previous Names
  • si:dkey-39f8.1
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits peptidase activity. Involved in several processes, including angiogenesis; notochord development; and regulation of Notch signaling pathway. Is expressed in several structures, including axial mesoderm; bone tissue; nervous system; pleuroperitoneal region; and ventral mandibular arch. Orthologous to human PAPPA2 (pappalysin 2).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 2 from Kjaer-Sorensen et al., 2014
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Kjaer-Sorensen et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pappa2 Human Ortholog
No data available
Associated With pappa2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR000800 Notch domain
Domain IPR006558 LamG-like jellyroll fold
Domain IPR008754 Peptidase M43, pregnancy-associated plasma-A
Family IPR026918 Pappalysin-2
Family IPR043543 Pappalysin-1/2
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Repeat IPR011936 Myxococcus cysteine-rich repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily LamG-like jellyroll fold Myxococcus cysteine-rich repeat Notch domain Pappalysin-1/2 Pappalysin-2 Peptidase M43, pregnancy-associated plasma-A Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily
UniProtKB:E9QCK7 1731
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations