ZFIN ID: ZDB-GENE-070912-282
Gene Name: dynein, axonemal, heavy chain 7
Gene Symbol: dnah7    Nomenclature History

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Previous Name: si:ch211-284h20.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding activity; and dynein light chain binding activity. Involved in determination of liver left/right asymmetry. Predicted to localize to the inner dynein arm. Is expressed in Kupffer's vesicle. Orthologous to human DNAH7 (dynein axonemal heavy chain 7).
Genome Resources: Alliance (1),  Gene:561639 (1),  Ensembl(GRCz11):ENSDARG00000060165 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Sampaio et al., 2014
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Segmentation:10-13 somites (14.0h-16.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1268 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1875 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2518 Point Mutation Unknown Premature Stop ENU
    sa7185 Point Mutation Unknown Splice Site ENU
    sa8404 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8862 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10194 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11115 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21492 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27405 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34646 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34647 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38742 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41422 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dnah7 N/A 1
    DISEASE ASSOCIATED WITH dnah7 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dnah7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component dynein complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR018247 EF-Hand 1, calcium-binding site
    Domain IPR002048 EF-hand domain
    Domain IPR003593 AAA+ ATPase domain
    Domain IPR004273 Dynein heavy chain region D6 P-loop domain
    Domain IPR013602 Dynein heavy chain, domain-2
    Domain IPR024317 Dynein heavy chain, AAA module D4
    Domain IPR024743 Dynein heavy chain, coiled coil stalk
    Domain IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
    Domain IPR035706 Dynein heavy chain, ATP-binding dynein motor region
    Domain IPR041228 Dynein heavy chain, C-terminal domain
    Domain IPR041466 Dynein heavy chain, AAA 5 extension domain
    Domain IPR041589 Dynein heavy chain 3, AAA+ lid domain
    Domain IPR041658 Dynein heavy chain AAA lid domain
    Family IPR026983 Dynein heavy chain
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR042219 Dynein heavy chain AAA lid domain superfamily
    Homologous_superfamily IPR042222 Dynein heavy chain, domain 2, N-terminal
    Homologous_superfamily IPR042228 Dynein heavy chain, domain 2, C-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnah7-202 (1)    Ensembl 12260
    dnah7-203 (1)    Ensembl 557
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnah7 No data available
    MARKER RELATIONSHIPS
    dnah7 Contained in: [BAC] CH211-260B17 (1), CH211-284H20 (1), DKEY-187E3 (1) (order this)
    dnah7 Encodes: [EST] wz12356
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_685051 (1) 12227 nt
    Genomic GenBank:BX323457 (1) 172918 nt
    Select Tool
    Polypeptide UniProtKB:F1Q8L1 (1) 4001 aa
    Sequence Information (all 23)
    ORTHOLOGY for dnah7 ( Chr: 9 )
    CITATIONS (20)