ZFIN ID: ZDB-GENE-030131-9881
Gene Name: TBC1 domain family, member 4
Gene Symbol: tbc1d4    Nomenclature History

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Previous Names: cb53 (1), sb:cb53, si:ch211-222g23.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have GTPase activator activity and Rab GTPase binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Is expressed in myotome; pancreatic bud; pronephric duct; and segmental plate. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D4 (TBC1 domain family member 4).
Genome Resources: Alliance (1),  Gene:321065 (1),  Ensembl(GRCz11):ENSDARG00000075156 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2001 [cb53]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7334 Point Mutation Unknown Splice Site ENU
sa13545 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34676 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tbc1d4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Diabetes mellitus, noninsulin-dependent, 5} 616087
    DISEASE ASSOCIATED WITH tbc1d4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of GTPase activity (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbc1d4-201 (1)    Ensembl 4019
    tbc1d4-202 (1)    Ensembl 756
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbc1d4 No data available
    MARKER RELATIONSHIPS
    tbc1d4 Contained in: [BAC] CH211-222G23 (1)
    tbc1d4 Encodes: [EST] cb53 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002663395 (1)
    Genomic GenBank:BX571809 (1) 193388 nt
    Select Tool
    Polypeptide UniProtKB:F1QE75 (1) 1230 aa
    Sequence Information (all 25)
    ORTHOLOGY for tbc1d4 ( Chr: 9 )
    CITATIONS (14)