ZFIN ID: ZDB-GENE-070730-1
Gene Name: cytochrome P450, family 2, subfamily U, polypeptide 1
Gene Symbol: cyp2u1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in several processes, including exogenous drug catabolic process; organic acid metabolic process; and xenobiotic metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 56. Orthologous to human CYP2U1 (cytochrome P450 family 2 subfamily U member 1).
Genome Resources: Alliance (1),  Gene:556280 (1),  Ensembl(GRCz11):ENSDARG00000026548 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cyp2u1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 56 Alliance Spastic paraplegia 56, autosomal recessive 615030
DISEASE ASSOCIATED WITH cyp2u1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component integral component of membrane (more)
Molecular Function heme binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Conserved_site IPR017972 Cytochrome P450, conserved site
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cyp2u1-201 (1)    Ensembl 1708
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyp2u1 No data available
MARKER RELATIONSHIPS
cyp2u1 Contained in: [BAC] DKEY-5K4 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001145564 (1)
Genomic GenBank:BX572104 (1) 114000 bp
Select Tool
Polypeptide UniProtKB:B8A5Q1 (1) 533 aa
Sequence Information (all 9)
ORTHOLOGY for cyp2u1 ( Chr: 1 )
CITATIONS (19)