ZFIN ID: ZDB-GENE-070720-19
Gene Name: quinoid dihydropteridine reductase b2
Gene Symbol: qdprb2    Nomenclature History

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Previous Names: dhprbb (1), zgc:171799

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase).
Genome Resources: Alliance (1),  Gene:101887190 (1), 
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH qdprb2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hyperphenylalaninemia, BH4-deficient, C 261630
DISEASE ASSOCIATED WITH qdprb2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process L-phenylalanine catabolic process (more)
Cellular Component cytoplasm (more)
Molecular Function 6,7-dihydropteridine reductase activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR002347 Short-chain dehydrogenase/reductase SDR
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA qdprb2-201 (1)    Ensembl 1137
ncRNA qdprb2-002 (1) 478
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM qdprb2 No data available
MARKER RELATIONSHIPS
qdprb2 Contained in: [BAC] CH211-182L2, DKEY-40H17 (1) (order this)
qdprb2 Encodes: [cDNA] MGC:171799 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001109710 (1) 865 bp
Genomic GenBank:BX005068 (1) 215007 bp Blast at MegaBLAST
Polypeptide UniProtKB:A0A2R8RM75 (1) 260 aa
Sequence Information (all 29)
ORTHOLOGY for qdprb2 ( Chr: 1 )
CITATIONS (12)