Gene

herc2

ID
ZDB-GENE-070718-6
Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2
Symbol
herc2 Nomenclature History
Previous Names
  • fd13h10
  • wu:fd13h10 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ubiquitin-protein transferase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With herc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 38 615516
[Skin/hair/eye pigmentation 1, blond/brown hair] 227220
[Skin/hair/eye pigmentation 1, blue/nonblue eyes] 227220
Associated With herc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR000569 HECT domain
Domain IPR001199 Cytochrome b5-like heme/steroid binding domain
Domain IPR004939 APC10/DOC domain
Domain IPR010606 Mib-herc2
Domain IPR021097 CPH domain
Domain IPR037976 HERC2, APC10 domain
Domain IPR041987 HERC2, zinc finger, ZZ-type
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009060 UBA-like superfamily
Homologous_superfamily IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily IPR014722 Ribosomal protein L2, domain 2
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
Homologous_superfamily IPR037252 Mib/herc2 domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Repeat IPR000408 Regulator of chromosome condensation, RCC1
Repeat IPR006624 Beta-propeller repeat TECPR
Domain Details Per Protein
Protein Length APC10/DOC domain Beta-propeller repeat TECPR CPH domain Cytochrome b5-like heme/steroid binding domain Cytochrome b5-like heme/steroid binding domain superfamily Galactose-binding-like domain superfamily HECT domain HECT, E3 ligase catalytic domain HERC2, APC10 domain HERC2, zinc finger, ZZ-type Mib-herc2 Mib/herc2 domain superfamily Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II Regulator of chromosome condensation, RCC1 Ribosomal protein L2, domain 2 UBA-like superfamily Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:X1WCH4 829
UniProtKB:E7EYK8 4830
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations