ZFIN ID: ZDB-GENE-070718-6
Gene Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Gene Symbol: herc2
Sequence Ontology ID : SO:0000704

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Previous Names: fd13h10, wu:fd13h10 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ubiquitin-protein transferase activity and zinc ion binding activity; predicted to be involved in cellular response to DNA damage stimulus and proteasome-mediated  ...
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10421 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13507 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13593 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13641 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15868 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20751 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20753 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30874 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33904 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33905 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33906 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38562 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40738 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40739 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20752 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44640 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH herc2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal recessive non-syndromic intellectual disability Mental retardation, autosomal recessive 38 615516
    [Skin/hair/eye pigmentation 1, blond/brown hair] 227220
    [Skin/hair/eye pigmentation 1, blue/nonblue eyes] 227220
    DISEASE ASSOCIATED WITH herc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein ubiquitination (more)
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000408 (1)
  • InterPro:IPR000433 (1)
  • InterPro:IPR000569 (1)
  • InterPro:IPR001199 (1)
  • InterPro:IPR004939 (1)
  • InterPro:IPR006624 (1)
  • InterPro:IPR008979 (1)
  • InterPro:IPR009060 (1)
  • InterPro:IPR009091 (1)
  • InterPro:IPR010606 (1)
  • InterPro:IPR014722 (1)
  • InterPro:IPR021097 (1)
  • InterPro:IPR035983 (1)
  • InterPro:IPR036400 (1)
  • InterPro:IPR037252 (1)
  • InterPro:IPR037976 (1)
  • PROSITE:PS00626 (1)
  • PROSITE:PS01357 (1)
  • PROSITE:PS50012 (1)
  • PROSITE:PS50135 (1)
  • PROSITE:PS50237 (1)
  • PROSITE:PS50255 (1)
  • PROSITE:PS51284 (1)
  • PROSITE:PS51416 (1)
  • Pfam:PF00173 (1)
  • Pfam:PF00415 (1)
  • Pfam:PF00569 (1)
  • Pfam:PF00632 (1)
  • Pfam:PF03256 (1)
  • Pfam:PF06701 (1)
  • Pfam:PF11515 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA herc2-202 (1) 2606
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM herc2 No data available
    MARKER RELATIONSHIPS
    herc2Contained in: [BAC] CH73-125I12 (1) (order this)
    herc2Encodes: [EST] fd13h10
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021471808 (1)
    Genomic GenBank:FP085470 (1) 60919bp
    Select Tool
    Polypeptide UniProtKB:E7EYK8 (1) 4830aa
    Sequence Clusters UniGene:159640 (1)
    Sequence Information (all 19)
    OTHER herc2 GENE PAGES
  • Alliance (1)
  • Gene:558479 (1)
  • VEGA:OTTDARG00000038251 (1)
  • Ensembl(GRCz11):ENSDARG00000073841 (2)
  • ORTHOLOGY for herc2 (Chr: 6)
    CITATIONS (17)