Gene

apobb.2

ID

ZDB-GENE-070705-554

Name

apolipoprotein Bb, tandem duplicate 2

Symbol

apobb.2 Nomenclature History

Previous Names

apobb2 (1)
apobl
si:dkeyp-88f5.1 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; lipoprotein transport; and triglyceride mobilization. Predicted to localize to low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

Genome Resources

Note

None

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apobb.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypobetalipoproteinemia 1	Alliance	Hypobetalipoproteinemia	615558
		Hypercholesterolemia, familial, 2	144010

Associated With apobb.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001747	Lipid transport protein, N-terminal
Domain	IPR009454	Lipid transport, open beta-sheet
Domain	IPR015255	Vitellinogen, open beta-sheet
Homologous_superfamily	IPR011030	Lipovitellin-phosvitin complex, superhelical domain
Homologous_superfamily	IPR015816	Vitellinogen, beta-sheet N-terminal
Homologous_superfamily	IPR015819	Lipid transport protein, beta-sheet shell