Gene
apobb.2
- ID
- ZDB-GENE-070705-554
- Name
- apolipoprotein Bb, tandem duplicate 2
- Symbol
- apobb.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; lipoprotein transport; and triglyceride mobilization. Predicted to act upstream of or within lipid transport. Predicted to be located in extracellular region. Predicted to be part of low-density lipoprotein particle; mature chylomicron; and very-low-density lipoprotein particle. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial hypobetalipoproteinemia 1 | Alliance | Hypobetalipoproteinemia | 615558 |
| Hypercholesterolemia, familial, 2 | 144010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR009454 | Lipid transport, open beta-sheet |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Family | IPR052418 | Apolipoprotein B |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
| Homologous_superfamily | IPR015816 | Vitellinogen, beta-sheet N-terminal |
| Homologous_superfamily | IPR015819 | Lipid transport protein, beta-sheet shell |
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein B | Lipid transport, open beta-sheet | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, open beta-sheet | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RMK1 | InterPro | 2633 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apobb.2-201
(1)
|
Ensembl | 8,195 nt | ||
| mRNA |
apobb.2-202
(1)
|
Ensembl | 7,605 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance