ZFIN Gene: apobb.2

ZFIN ID: ZDB-GENE-070705-554

ZFIN ID: ZDB-GENE-070705-554

Gene Name:

apolipoprotein Bb, tandem duplicate 2

Gene Symbol:

apobb.2 Nomenclature History

Previous Names:

apobb2 (1), apobl, si:dkeyp-88f5.1 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Predicted to have lipid transporter activity. Predicted to be involved in lipid transport. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).

Genome Resources:

Alliance (1), Gene:100330435 (1), Ensembl(GRCz11):ENSDARG00000075016

GENE EXPRESSION
All Expression Data:	5 figures from 2 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
	liver yolk syncytial layer
High Throughput Expression:	Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa6658	Point Mutation	Unknown	Premature Stop	ENU
sa17651	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23825	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37185	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43552	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH apobb.2 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hypobetalipoproteinemia 1	Alliance	Hypobetalipoproteinemia	615558
		Hypercholesterolemia, familial, 2	144010

DISEASE ASSOCIATED WITH apobb.2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	lipid transport (more)
Cellular Component	low-density lipoprotein particle (more)
Molecular Function	lipid transporter activity (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	apobb.2-201 (1)	8195	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS

Addgene:PCRII apoBb.2

CONSTRUCTS WITH SEQUENCES FROM apobb.2 No data available

MARKER RELATIONSHIPS

apobb.2 Contained in:

[BAC] DKEYP-88F5 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_002665806 (1)	8104 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR545462 (1)	199482 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A286YBH9 (1)	2534 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 10)

ORTHOLOGY for apobb.2 ( Chr: 20 )

CITATIONS (18)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: