ZFIN ID: ZDB-GENE-070705-451
Gene Name: salt-inducible kinase 2a
Gene Symbol: sik2a    Nomenclature History

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Previous Names: si:dkey-27p23.1, snf1lk2a

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of TOR signaling; and protein phosphorylation. Predicted to localize to the cytoplasm; nucleotide-activated protein kinase complex; and nucleus. Orthologous to human SIK2 (salt inducible kinase 2).
Genome Resources: Alliance (1),  Gene:100126142 (1),  Ensembl(GRCz11):ENSDARG00000079618 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26591 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sik2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sik2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR015940 Ubiquitin-associated domain
    Domain IPR034672 Salt-Inducible kinase, catalytic domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sik2a-203 (1)    Ensembl 2529
    ncRNA sik2a-002 (1) 915
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sik2a No data available
    MARKER RELATIONSHIPS
    sik2a Contained in: [BAC] DKEY-27P23 (1) (order this)
    sik2a Encodes: [cDNA] MGC:171729 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001109868 (1) 1366 nt
    Genomic RefSeq:NW_018394617 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A5PN50 (1) 842 aa
    Sequence Information (all 18)
    ORTHOLOGY for sik2a ( Chr: 5 )
    CITATIONS (14)