ZFIN ID: ZDB-GENE-070705-4
Gene Name: gephyrin b
Gene Symbol: gphnb    Nomenclature History

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Previous Names: fj59a01, wu:fj59a01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have molybdopterin adenylyltransferase activity and molybdopterin molybdotransferase activity. Involved in glycine receptor clustering. Predicted to localize to several cellular components, including dendrite; postsynaptic membrane; and postsynaptic specialization. Is expressed in head; rhombomere; spinal cord; and spinal cord interneuron. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin).
Genome Resources: Alliance (1),  Gene:100007749 (1),  Ensembl(GRCz11):ENSDARG00000100851 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013932Tg Transgenic Insertion Unknown Unknown DNA
sa37171 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43543 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43544 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45718 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gphnb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gphnb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    molybdenum cofactor deficiency type C Alliance Molybdenum cofactor deficiency C 615501
    DISEASE ASSOCIATED WITH gphnb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glycine receptor clustering (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gphnb-203 (1)    Ensembl 2680
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-gphn monoclonal IgG1 Mouse IHC, WB BD Biosciences
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gphnb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hcrt:gphnb-EGFP) hcrt EGFPgphnb Danio rerio 1 1
    Tg(UAS:gphnb-EGFP) UAS EGFPgphnb Danio rerio 1 1
    MARKER RELATIONSHIPS
    gphnb Contained in: [Fosmid] CH1073-186E1 (1), CH1073-297E15 (1)
    gphnb Encodes: [EST] fj59a01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001172400 (1) 2391 nt
    Genomic GenBank:CU104745 (1) 39650 nt
    Select Tool
    Polypeptide UniProtKB:D3KYL2 (1) 796 aa
    Sequence Information (all 44)
    ORTHOLOGY for gphnb ( Chr: 20 )
    CITATIONS (26)