ZFIN ID: ZDB-GENE-070705-171
Gene Name: DIS3 like 3'-5' exoribonuclease 2
Gene Symbol: dis3l2    Nomenclature History

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Previous Name: si:ch211-273k1.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have 3'-5'-exoribonuclease activity. Involved in pronephros development. Predicted to localize to P-body and exosome (RNase complex). Is expressed in pronephros. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2).
Genome Resources: Alliance (1),  Gene:566106 (1),  Ensembl(GRCz11):ENSDARG00000033259 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa25753 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-dis3l2 N/A 1
MO2-dis3l2 N/A 1
DISEASE ASSOCIATED WITH dis3l2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Perlman syndrome Alliance Perlman syndrome 267000
DISEASE ASSOCIATED WITH dis3l2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process pronephros development (more)
Cellular Component cytoplasm (more)
Molecular Function 3'-5'-exoribonuclease activity (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dis3l2-201 (1)    Ensembl 5108
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dis3l2 No data available
MARKER RELATIONSHIPS
dis3l2 Contained in: [BAC] CH211-273K1 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005163248 (1)
Genomic GenBank:BX001029 (1) 141447 nt
Select Tool
Polypeptide UniProtKB:E7F350 (1) 995 aa
Sequence Information (all 6)
ORTHOLOGY for dis3l2 ( Chr: 2 )
CITATIONS (19)