Gene
lyst
- ID
- ZDB-GENE-070702-1
- Name
- lysosomal trafficking regulator
- Symbol
- lyst Nomenclature History
- Previous Names
-
- si:ch211-30i2.1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be located in cytoplasm. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kim et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Chediak-Higashi syndrome | Alliance | Chediak-Higashi syndrome | 214500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR000409 | BEACH domain |
| Domain | IPR023362 | PH-BEACH domain |
| Family | IPR050865 | BEACH Domain-Containing |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036372 | BEACH domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | BEACH domain | BEACH Domain-Containing | BEACH domain superfamily | PH-BEACH domain | PH-like domain superfamily | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z3Z4 | InterPro | 3826 | |||||||||
| UniProtKB:A0A8M6Z2E9 | InterPro | 3886 | |||||||||
| UniProtKB:A0A8M9PU84 | InterPro | 3832 | |||||||||
| UniProtKB:A0A8M3AZH9 | InterPro | 3832 | |||||||||
| UniProtKB:A0AB32TLB9 | InterPro | 3886 | |||||||||
| UniProtKB:A0AB32TN77 | InterPro | 3826 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available