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Gene

lyst

ID
ZDB-GENE-070702-1
Name
lysosomal trafficking regulator
Symbol
lyst Nomenclature History
Previous Names
  • si:ch211-30i2.1
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within lysosome organization. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kim et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lyst Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Chediak-Higashi syndrome Alliance Chediak-Higashi syndrome 214500
Associated With lyst Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR000409 BEACH domain
Domain IPR017986 WD40-repeat-containing domain
Domain IPR023362 PH-BEACH domain
Family IPR030464 Lysosomal-trafficking regulator
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Homologous_superfamily IPR036372 BEACH domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length BEACH domain BEACH domain superfamily Lysosomal-trafficking regulator PH-BEACH domain WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:E9QFZ1 2666
UniProtKB:B7ZCY9 2660
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations