ZFIN ID: ZDB-GENE-070604-3
Gene Name: inositol 1,4,5-trisphosphate receptor, type 1a
Gene Symbol: itpr1a    Nomenclature History

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Previous Names: ITPR1b1 (1), ITPR1b3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1).
Genome Resources: Alliance (1),  Gene:567611 (1),  Ensembl(GRCz11):ENSDARG00000014655 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH itpr1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gillespie syndrome Alliance Gillespie syndrome 206700
spinocerebellar ataxia type 15 Alliance Spinocerebellar ataxia 15 606658
spinocerebellar ataxia type 29 Alliance Spinocerebellar ataxia 29, congenital nonprogressive 117360
DISEASE ASSOCIATED WITH itpr1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion transmembrane transport (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function calcium channel activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA itpr1a-202 (1)    Ensembl 8747
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM itpr1a No data available
MARKER RELATIONSHIPS
itpr1a Contained in: [BAC] DKEY-74L3 (1) (order this), DKEY-105A17 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005166095 (1) 9166 nt
Genomic GenBank:BX548005 218236 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A2R8QAR1 (1) 2745 aa
Sequence Information (all 51)
ORTHOLOGY for itpr1a ( Chr: 6 )
CITATIONS (23)