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Gene

flnca

ID
ZDB-GENE-070503-1
Name
filamin C, gamma a (actin binding protein 280)
Symbol
flnca Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable actin binding activity. Acts upstream of or within locomotory behavior and muscle cell cellular homeostasis. Is expressed in adaxial cell; muscle pioneer; and slow muscle cell. Human ortholog(s) of this gene implicated in distal muscular dystrophy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flnca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
distal muscular dystrophy 4 Alliance Myopathy, distal, 4 614065
hypertrophic cardiomyopathy 26 Alliance Cardiomyopathy, familial hypertrophic, 26 617047
hypertrophic cardiomyopathy 26 Alliance Cardiomyopathy, familial restrictive 5 617047
myofibrillar myopathy 5 Alliance Myopathy, myofibrillar, 5 609524
Associated With flnca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001715 Calponin homology domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036872 CH domain superfamily
Repeat IPR001298 Filamin/ABP280 repeat
Repeat IPR017868 Filamin/ABP280 repeat-like
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily Filamin/ABP280 repeat Filamin/ABP280 repeat-like Immunoglobulin E-set Immunoglobulin-like fold
UniProtKB:A0A0R4IUS4 2702
UniProtKB:E7F1L7 2719
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations