Gene

ptpro

ID
ZDB-GENE-070424-54
Name
protein tyrosine phosphatase receptor type O
Symbol
ptpro Nomenclature History
Previous Names
  • zgc:158179
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have protein tyrosine phosphatase activity. Involved in cerebellum morphogenesis and regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; eye; optic cup; optic vesicle; and tail bud. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Liao et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptpro Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephrotic syndrome type 6 Alliance Nephrotic syndrome, type 6 614196
Associated With ptpro Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 PTP type protein phosphatase
Domain IPR000387 Tyrosine specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR003961 Fibronectin type III
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTP type protein phosphatase Tyrosine specific protein phosphatases domain
UniProtKB:C7U140 88
UniProtKB:A0A2R8QJG1 357
UniProtKB:A0A0R4IA95 378
UniProtKB:A0A0R4IIG9 866
UniProtKB:Q6NWB5 341
UniProtKB:A0A0R4IJG0 385
UniProtKB:A4IFW3 1238
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptpro polyclonal IgG Rabbit
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations