ZFIN ID: ZDB-GENE-070424-129
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a
Gene Symbol: grin2aa    Nomenclature History

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Previous Names: NR2A.2 (1), si:ch211-13c14.1, zNMDA-2A.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have NMDA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to localize to NMDA selective glutamate receptor complex and postsynaptic density membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000034493 (2)
GENE EXPRESSION
All Expression Data: Fig. 7 from Cox et al., 2005
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a280 Complex Unknown Unknown CRISPR
sa13836 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14573 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40072 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40073 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-grin2aa 1
    DISEASE ASSOCIATED WITH grin2aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Landau-Kleffner syndrome Alliance Epilepsy, focal, with speech disorder and with or without mental retardation 245570
    DISEASE ASSOCIATED WITH grin2aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA grin2aa-201 (1)    Ensembl 9441
    ncRNA grin2aa-002 (1) 487
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM grin2aa No data available
    MARKER RELATIONSHIPS
    grin2aa Contained in: [BAC] CH211-13C14 (1), DKEY-77J9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX908803 (1) 186802 nt
    Select Tool
    Polypeptide UniProtKB:F6P6I2 (1) 1460 aa
    Sequence Information (all 4)
    ORTHOLOGY for grin2aa ( Chr: 3 )
    CITATIONS (21)