Gene

fkrp

ID

ZDB-GENE-070412-4

Name

fukutin related protein

Symbol

fkrp Nomenclature History

Previous Names

zgc:162829

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Involved in several processes, including muscle fiber development; regulation of protein glycosylation; and vasculogenesis. Predicted to localize to Golgi apparatus. Is expressed in several structures, including cloacal chamber; immature eye; nervous system; neural keel; and otic vesicle. Used to study muscular dystrophy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and muscular dystrophy (multiple). Orthologous to human FKRP (fukutin related protein).

Genome Resources

Note

None

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fkrp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2I	Alliance	Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 5	607155
congenital muscular dystrophy-dystroglycanopathy type A5	Alliance	Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 5	613153
muscular dystrophy-dystroglycanopathy type B5	Alliance	Muscular dystrophy-dystroglycanopathy (congenital with or without mental retardation), type B, 5	606612

Associated With fkrp Via Experimental Models

Human Disease	Fish	Conditions	Citations
muscular dystrophy	AB + MO1-fkrp	control	Thornhill et al., 2008

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007074	LicD family

Domain Details Per Protein

Protein	Length	LicD family
UniProtKB:Q0PIP5 InterPro	536
UniProtKB:A4QP37 InterPro	536

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fkrp	polyclonal	fkrp		Rabbit	WB	Life Technologies (Invitrogen)	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations