ZFIN Gene: ncapg2

ZFIN ID: ZDB-GENE-070410-100

ZFIN ID: ZDB-GENE-070410-100

Gene Name:

non-SMC condensin II complex, subunit G2

Gene Symbol:

ncapg2 Nomenclature History

Previous Names:

id:ibd2775, zgc:162881

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to be involved in mitotic sister chromatid segregation. Predicted to localize to condensin complex and nucleus. Is expressed in brain and spinal cord. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2).

Genome Resources:

Alliance (1), Gene:100037337 (1), Ensembl(GRCz11):ENSDARG00000060023 (2)

GENE EXPRESSION
Directly Submitted Expression Data:	1 figure (1 image) from Kudoh et al., 2001 [ibd2775]
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
	brain spinal cord
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la026064Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa2364	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa10405	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa12675	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16326	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa18884	Point Mutation	Unknown	Splice Site	ENU
sa40970	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40971	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-ncapg2		1
CRISPR2-ncapg2		1
MO1-ncapg2	N/A	1

PHENOTYPE

Data:	5 figures from Khan et al., 2019
Observed in:	brain mitotic cell cycle process cerebellum forebrain midbrain boundary apoptotic process head optic tectum pronephros proximal convoluted tubule proximal straight tubule

DISEASE ASSOCIATED WITH ncapg2 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Khan-Khan-Katsanis syndrome	618460

DISEASE ASSOCIATED WITH ncapg2 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
autosomal recessive disease	WT + CRISPR2-ncapg2	standard conditions	Khan et al., 2019
	WT + MO1-ncapg2	standard conditions	Khan et al., 2019
	WT + CRISPR1-ncapg2	standard conditions	Khan et al., 2019

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cell cycle (more)
Cellular Component	nucleus (more)

GO Terms (all 6)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ncapg2-201 (1)	4183	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ncapg2-202 (1)	290	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ncapg2 No data available

MARKER RELATIONSHIPS

ncapg2 Contained in:	[BAC] CH211-212M22 (1), DKEY-125M8 (1) (order this), DKEY-200K18 (1) (order this)
ncapg2 Encodes:	[EST] ibd2775 [cDNA] MGC:162881 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001089492 (1)	3723 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_018394703 (1)		Blast at MegaBLAST
Polypeptide	UniProtKB:E7FH61 (1)	1140 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 26)

ORTHOLOGY for ncapg2 ( Chr: 7 )

CITATIONS (25)

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