Gene

setx

ID
ZDB-GENE-070402-1
Name
senataxin
Symbol
setx Nomenclature History
Previous Names
  • wu:fj92h09
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to localize to nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With setx Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 4 Alliance Amyotrophic lateral sclerosis 4, juvenile 602433
ataxia with oculomotor apraxia type 2 Alliance Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 606002
Associated With setx Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024481 Helicase Sen1, N-terminal
Domain IPR041677 DNA2/NAM7 helicase, helicase domain
Domain IPR041679 DNA2/NAM7 helicase-like, C-terminal
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Armadillo-type fold DNA2/NAM7 helicase, helicase domain DNA2/NAM7 helicase-like, C-terminal Helicase Sen1, N-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A2R8Q0K5 2240
UniProtKB:F8W2T6 294
UniProtKB:E7FBJ2 2368
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations