ZFIN ID: ZDB-GENE-070323-1
Gene Name: cathepsin Bb
Gene Symbol: ctsbb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B).
Genome Resources: Alliance (1),  Gene:569298 (1),  Ensembl(GRCz11):ENSDARG00000101051 (1)
GENE EXPRESSION
All Expression Data: Fig. 1 from Klangnurak et al., 2018
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43551 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ctsbb N/A 1
    MO2-ctsbb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctsbb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Keratolytic winter erythema 148370
    DISEASE ASSOCIATED WITH ctsbb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular space (more)
    Molecular Function cysteine-type endopeptidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctsbb-201 (1)    Ensembl 375
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctsbb No data available
    MARKER RELATIONSHIPS
    ctsbb Contained in: [BAC] CH73-107C13 (1)
    ctsbb Encodes: [cDNA] MGC:136756 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110478 (1) 2091 nt
    Genomic GenBank:CU207296 (1) 98771 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IUN6 (1) 327 aa
    Sequence Information (all 15)
    ORTHOLOGY for ctsbb ( Chr: 20 )
    CITATIONS (24)