ZFIN ID: ZDB-GENE-070228-2
Gene Name: aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)
Gene Symbol: aldh5a1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have NAD binding activity and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in galactosylceramide metabolic process; gamma-aminobutyric acid catabolic process; and short-chain fatty acid metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1).
Genome Resources: Alliance (1),  Gene:565235 (1),  Ensembl(GRCz11):ENSDARG00000076544 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17724 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aldh5a1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH aldh5a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    succinic semialdehyde dehydrogenase deficiency Alliance Succinic semialdehyde dehydrogenase deficiency 271980
    DISEASE ASSOCIATED WITH aldh5a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process galactosylceramide metabolic process (more)
    Cellular Component mitochondrion (more)
    Molecular Function NAD binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh5a1-201 (1)    Ensembl 1918
    aldh5a1-202 (1)    Ensembl 1823
    ncRNA aldh5a1-002 (1)    Ensembl 539
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh5a1 No data available
    MARKER RELATIONSHIPS
    aldh5a1 Contained in: [BAC] DKEY-209J17 (order this)
    aldh5a1 Encodes: [cDNA] MGC:162155 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110468 (1) 1842 nt
    Genomic GenBank:BX005341 (1) 158356 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IIB7 (1) 522 aa
    Sequence Information (all 15)
    ORTHOLOGY for aldh5a1 ( Chr: 16 )
    CITATIONS (26)