Gene

aldh5a1

ID
ZDB-GENE-070228-2
Name
aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)
Symbol
aldh5a1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have NAD binding activity and succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in galactosylceramide metabolic process; gamma-aminobutyric acid catabolic process; and short-chain fatty acid metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1).
Genome Resources
Note
None
Expression
All Expression Data
from Lodd et al., 2019
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aldh5a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
succinic semialdehyde dehydrogenase deficiency Alliance Succinic semialdehyde dehydrogenase deficiency 271980
Associated With aldh5a1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
Domain IPR015590 Aldehyde dehydrogenase domain
Family IPR010102 Succinate semialdehyde dehydrogenase
Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
Homologous_superfamily IPR016163 Aldehyde dehydrogenase, C-terminal
Domain Details Per Protein
Protein Length Aldehyde dehydrogenase, C-terminal Aldehyde dehydrogenase, cysteine active site Aldehyde dehydrogenase domain Aldehyde dehydrogenase, N-terminal Aldehyde/histidinol dehydrogenase Succinate semialdehyde dehydrogenase
UniProtKB:A0A0R4IIB7 522
UniProtKB:A4IG36 404
UniProtKB:A0A2R8RQM6 522
UniProtKB:F1QE89 426
UniProtKB:F1R9T0 480
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations