| ZFIN ID: ZDB-GENE-070216-1 |
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| Gene Name: | orthopedia homeobox a | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | otpa Nomenclature History |
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Attributions
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| Previous Names: | otp2 (1), otp, otpb | |||||||||||||
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Attributions for Alias: {{control.newAlias}}
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 21 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have sequence-specific DNA binding activity. Involved in nervous system development; social behavior; and visual behavior. Predicted to localize to the nucleus. Is expressed in hematopoietic stem cell and nervous system. Orthologous to human OTP (orthopedia homeobox). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:560759 (1), Ensembl(GRCz11):ENSDARG00000014201 (2) | |||||||||||||
PHENOTYPE
| Data: | 9 figures from 5 publications |
| Observed in: |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | forebrain neuron development (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | DNA binding (more) |
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Domain | IPR001356 | Homeobox domain |
| Domain | IPR003654 | OAR domain |
| Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
otpa-201
(1)
|
1852 |
Select Tool
|
|
|
otpa-202
(1)
|
1150 |
Select Tool
|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM otpa
| Construct | Regulatory Regions | Coding Sequences | Species | Tg Lines | Publications |
|---|---|---|---|---|---|
| Et(otpa:GFP) | otpa | GFP | Danio rerio | 1 | 4 |
| Tg(FRT-Xla.Actc1:DsRed-GAB-FRT-LOXP,otpa-LOXP-E1B:mmGFP-5HS4,myl7:RFP) | E1B, FRT, LOXP, myl7, otpa | 5HS4, DsRed, FRT, GAB, GFP, LOXP, RFP | Danio rerio, Xenopus laevis | 1 | 2 |
| Tg(hsp70l:otpa,EGFP) | hsp70l | EGFP, otpa | Danio rerio | 1 | 2 |
| Tg(hsp70l:otpa,hsp70l:YFP) | hsp70l | otpa, YFP | Danio rerio | 1 | 2 |
| Tg(otpa-E1B:LOX2272-LOXP-MA-RFP-LOX2272-MA-YFP-LOXP-MA-CFP) | E1B, otpa | CFP, LOX2272, LOXP, MA, RFP, YFP | Danio rerio | 1 | 1 |
| Tg(otpa-E1B:NTR-GFP) | E1B, otpa | GFP, NTR | Danio rerio | 1 | 2 |
| Tg(otpa-E1B:RFP-CAAX) | E1B, otpa | CAAX, RFP | Danio rerio | 1 | 3 |
| Tg(otpa-hsp70l:GAL4-VP16,myl7:EGFP) | hsp70l, myl7, otpa | EGFP, GAL4, VP16 | Danio rerio | 2 | 2 |
| Tg(otpa-hsp70l:GCaMP3.0) | hsp70l, otpa | GCaMP | Danio rerio | 1 | 1 |
| Tg(otpa-hsp70l:GCaMP6s) | hsp70l, otpa | GCaMP | Danio rerio | 1 | 3 |
MARKER RELATIONSHIPS
| otpa Contained in: | [BAC] DKEYP-1D11 (1) |
| otpa Encodes: | [cDNA] MGC:193949 (1), MGC:193951 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001128703 (1) | 1064 bp |
Select Tool
|
| Genomic | GenBank:CU459136 (1) | 159343 bp | |
| Polypeptide | UniProtKB:B3DGA5 (1) | 332 aa |
Select Tool
|
| Sequence Clusters | UniGene:87162 (1) |
ORTHOLOGY for otpa (
Chr:
21
)
CITATIONS (59)