ZFIN ID: ZDB-GENE-070216-1
Gene Name: orthopedia homeobox a
Gene Symbol: otpa    Nomenclature History

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Previous Names: otp2 (1), otp, otpb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in nervous system development; social behavior; and visual behavior. Predicted to localize to nucleus. Is expressed in hematopoietic stem cell and nervous system. Orthologous to human OTP (orthopedia homeobox).
Genome Resources: Alliance (1),  Gene:560759 (1),  Ensembl(GRCz11):ENSDARG00000014201 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
az7 Indel Unknown Unknown CRISPR
az8 Indel Unknown Unknown CRISPR
m866 Unknown Unknown Unknown ENU
sa44954 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-otpa 1
    MO1-otpa N/A 4
    MO2-otpa N/A 1
    DISEASE ASSOCIATED WITH otpa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH otpa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process forebrain neuron development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA otpa-201 (1)    Ensembl 1852
    otpa-202 (1)    Ensembl 1150
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-otpa Rat IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM otpa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Et(otpa:GFP) otpa GFP Danio rerio 1 4
    Tg(FRT-Xla.Actc1:DsRed-GAB-FRT-LOXP,otpa-LOXP-E1B:mmGFP-5HS4,myl7:RFP) E1BFRTLOXPmyl7otpa 5HS4DsRedFRTGABGFPLOXPRFP Danio rerioXenopus laevis 1 2
    Tg(hsp70l:otpa,EGFP) hsp70l EGFPotpa Danio rerio 1 2
    Tg(hsp70l:otpa,hsp70l:YFP) hsp70l otpaYFP Danio rerio 1 2
    Tg(otpa-E1B:LOX2272-LOXP-MA-RFP-LOX2272-MA-YFP-LOXP-MA-CFP) E1Botpa CFPLOX2272LOXPMARFPYFP Danio rerio 1 1
    Tg(otpa-E1B:NTR-GFP) E1Botpa GFPNTR Danio rerio 1 2
    Tg(otpa-E1B:RFP-CAAX) E1Botpa CAAXRFP Danio rerio 1 3
    Tg(otpa-hsp70l:GAL4-VP16,myl7:EGFP) hsp70lmyl7otpa EGFPGAL4VP16 Danio rerio 2 2
    Tg(otpa-hsp70l:GCaMP3.0) hsp70lotpa GCaMP Danio rerio 1 1
    Tg(otpa-hsp70l:GCaMP6s) hsp70lotpa GCaMP Danio rerio 1 3
    MARKER RELATIONSHIPS
    otpa Contained in: [BAC] DKEYP-1D11 (1)
    otpa Encodes: [cDNA] MGC:193949 (1), MGC:193951 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128703 (1) 1064 nt
    Genomic GenBank:CU459136 (1) 159343 nt
    Select Tool
    Polypeptide UniProtKB:B3DGA5 (1) 332 aa
    Sequence Information (all 16)
    ORTHOLOGY for otpa ( Chr: 21 )
    CITATIONS (60)