ZFIN ID: ZDB-GENE-070216-1
Gene Name: orthopedia homeobox a
Gene Symbol: otpa    Nomenclature History

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Previous Names: otp2 (1), otp, otpb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in nervous system development; social behavior; and visual behavior. Predicted to localize to the nucleus. Is expressed in hematopoietic stem cell and nervous system. Orthologous to human OTP (orthopedia homeobox).
Genome Resources: Alliance (1),  Gene:560759 (1),  Ensembl(GRCz11):ENSDARG00000014201 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
az7 Indel Unknown Unknown CRISPR
az8 Indel Unknown Unknown CRISPR
m866 Unknown Unknown Unknown ENU
sa44954 Point Mutation Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-otpa 1
MO1-otpa N/A 4
MO2-otpa N/A 1
DISEASE ASSOCIATED WITH otpa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH otpa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process forebrain neuron development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Conserved_site IPR017970 Homeobox, conserved site
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA otpa-201 (1)    Ensembl 1852
otpa-202 (1)    Ensembl 1150
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-otpa Rat IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM otpa
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Et(otpa:GFP) otpa GFP Danio rerio 1 4
Tg(FRT-Xla.Actc1:DsRed-GAB-FRT-LOXP,otpa-LOXP-E1B:mmGFP-5HS4,myl7:RFP) E1BFRTLOXPmyl7otpa 5HS4DsRedFRTGABGFPLOXPRFP Danio rerioXenopus laevis 1 2
Tg(hsp70l:otpa,EGFP) hsp70l EGFPotpa Danio rerio 1 2
Tg(hsp70l:otpa,hsp70l:YFP) hsp70l otpaYFP Danio rerio 1 2
Tg(otpa-E1B:LOX2272-LOXP-MA-RFP-LOX2272-MA-YFP-LOXP-MA-CFP) E1Botpa CFPLOX2272LOXPMARFPYFP Danio rerio 1 1
Tg(otpa-E1B:NTR-GFP) E1Botpa GFPNTR Danio rerio 1 2
Tg(otpa-E1B:RFP-CAAX) E1Botpa CAAXRFP Danio rerio 1 3
Tg(otpa-hsp70l:GAL4-VP16,myl7:EGFP) hsp70lmyl7otpa EGFPGAL4VP16 Danio rerio 2 2
Tg(otpa-hsp70l:GCaMP3.0) hsp70lotpa GCaMP Danio rerio 1 1
Tg(otpa-hsp70l:GCaMP6s) hsp70lotpa GCaMP Danio rerio 1 3
MARKER RELATIONSHIPS
otpa Contained in: [BAC] DKEYP-1D11 (1)
otpa Encodes: [cDNA] MGC:193949 (1), MGC:193951 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001128703 (1) 1064 bp
Genomic GenBank:CU459136 (1) 159343 bp
Select Tool
Polypeptide UniProtKB:B3DGA5 (1) 332 aa
Sequence Clusters UniGene:87162 (1)
Sequence Information (all 17)
ORTHOLOGY for otpa ( Chr: 21 )
CITATIONS (59)