ZFIN Gene: otpa

ZFIN ID: ZDB-GENE-070216-1

ZFIN ID: ZDB-GENE-070216-1

Gene Name:

orthopedia homeobox a

Gene Symbol:

otpa

Sequence Ontology ID :

SO:0000704

Previous Names:

otp2 (1), otp, otpb

Location:

Chr: 21 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have sequence-specific DNA binding activity. Involved in nervous system development; social behavior; and visual behavior. Predicted to localize to the nucleus. Orthologous to human OTP ...

GENE EXPRESSION
All Expression Data:	26 figures from 13 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
	caudal parvocellular preoptic nucleus caudal periventricular hypothalamus medial region caudal tuberculum dorsal region caudal tuberculum diencephalon ventral region diencephalon dopaminergic neuron hematopoietic stem cell hindbrain anterior side hindbrain hypophysis hypothalamus posterior region hypothalamus lateral forebrain bundle magnocellular preoptic nucleus midbrain preoptic area brain nucleus preoptic area rostral parvocellular preoptic nucleus telencephalon telencephalon diencephalon boundary ventral thalamus whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen
az7	Indel	Unknown	Unknown	CRISPR
az8	Indel	Unknown	Unknown	CRISPR
m866	Unknown	Unknown	Unknown	ENU
sa44954	Point Mutation	Unknown	Unknown	ENU

Targeting reagents:

PHENOTYPE

Data:	9 figures from 5 publications
Observed in:	caudal tuberculum dopaminergic neuron caudal tuberculum dopaminergic neuron hypothalamus dopaminergic neuron phototaxis preoptic area neurosecretory neuron response to stress social behavior spinal cord motor neuron visual behavior

DISEASE ASSOCIATED WITH otpa HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH otpa VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	forebrain neuron development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000047 (1) InterPro:IPR001356 (1) InterPro:IPR003654 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1)	PROSITE:PS00027 (1) PROSITE:PS50071 (1) PROSITE:PS50803 (1)	Pfam:PF00046 (1) Pfam:PF03826 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	otpa-201 (1)	1852	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	otpa-202 (1)	1150	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES

Ab1-otpa (1)

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM otpa

MARKER RELATIONSHIPS

otpaContained in:	[BAC] DKEYP-1D11 (1)
otpaEncodes:	[cDNA] MGC:193949 (1) (order this), MGC:193951 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001128703 (1)	1064bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU459136 (1)	159343bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DGA5 (1)	332aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:87162 (1)

Sequence Information (all 17)

OTHER otpa GENE PAGES

Alliance (1)

Gene:560759 (1)

VEGA:OTTDARG00000031279 (1)

Ensembl(GRCz11):ENSDARG00000014201 (2)

ORTHOLOGY for otpa (Chr: 21)

CITATIONS (56)

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