ZFIN Gene: otpa

ZFIN ID: ZDB-GENE-070216-1

ZFIN ID: ZDB-GENE-070216-1

Gene Name:

orthopedia homeobox a

Gene Symbol:

otpa Nomenclature History

Previous Names:

otp2 (1), otp, otpb

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have sequence-specific DNA binding activity. Involved in nervous system development; social behavior; and visual behavior. Predicted to localize to nucleus. Is expressed in hematopoietic stem cell and nervous system. Orthologous to human OTP (orthopedia homeobox).

Genome Resources:

Alliance (1), Gene:560759 (1), Ensembl(GRCz11):ENSDARG00000014201 (2)

GENE EXPRESSION
All Expression Data:	26 figures from 13 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
	caudal parvocellular preoptic nucleus caudal periventricular hypothalamus medial region caudal tuberculum dorsal region caudal tuberculum diencephalon ventral region diencephalon dopaminergic neuron hematopoietic stem cell hindbrain anterior side hindbrain hypophysis hypothalamus posterior region hypothalamus lateral forebrain bundle magnocellular preoptic nucleus midbrain preoptic area brain nucleus preoptic area rostral parvocellular preoptic nucleus telencephalon telencephalon diencephalon boundary ventral thalamus whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
az7	Indel	Unknown	Unknown	CRISPR
az8	Indel	Unknown	Unknown	CRISPR
m866	Unknown	Unknown	Unknown	ENU
sa44954	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-otpa	az7 az8	1
MO1-otpa	N/A	4
MO2-otpa	N/A	1

PHENOTYPE

Data:	9 figures from 5 publications
Observed in:	caudal tuberculum dopaminergic neuron caudal tuberculum dopaminergic neuron hypothalamus dopaminergic neuron phototaxis preoptic area neurosecretory neuron response to stress social behavior spinal cord motor neuron visual behavior

DISEASE ASSOCIATED WITH otpa HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH otpa VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	forebrain neuron development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	otpa-201 (1)	1852	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	otpa-202 (1)	1150	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-otpa			Rat	IHC		1

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM otpa

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Et(otpa:GFP)	otpa	GFP	Danio rerio	1	4
Tg(FRT-Xla.Actc1:DsRed-GAB-FRT-LOXP,otpa-LOXP-E1B:mmGFP-5HS4,myl7:RFP)	E1B, FRT, LOXP, myl7, otpa	5HS4, DsRed, FRT, GAB, GFP, LOXP, RFP	Danio rerio, Xenopus laevis	1	2
Tg(hsp70l:otpa,EGFP)	hsp70l	EGFP, otpa	Danio rerio	1	2
Tg(hsp70l:otpa,hsp70l:YFP)	hsp70l	otpa, YFP	Danio rerio	1	2
Tg(otpa-E1B:LOX2272-LOXP-MA-RFP-LOX2272-MA-YFP-LOXP-MA-CFP)	E1B, otpa	CFP, LOX2272, LOXP, MA, RFP, YFP	Danio rerio	1	1
Tg(otpa-E1B:NTR-GFP)	E1B, otpa	GFP, NTR	Danio rerio	1	2
Tg(otpa-E1B:RFP-CAAX)	E1B, otpa	CAAX, RFP	Danio rerio	1	3
Tg(otpa-hsp70l:GAL4-VP16,myl7:EGFP)	hsp70l, myl7, otpa	EGFP, GAL4, VP16	Danio rerio	2	2
Tg(otpa-hsp70l:GCaMP3.0)	hsp70l, otpa	GCaMP	Danio rerio	1	1
Tg(otpa-hsp70l:GCaMP6s)	hsp70l, otpa	GCaMP	Danio rerio	1	3

MARKER RELATIONSHIPS

otpa Contained in:	[BAC] DKEYP-1D11 (1)
otpa Encodes:	[cDNA] MGC:193949 (1), MGC:193951 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001128703 (1)	1064 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU459136 (1)	159343 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DGA5 (1)	332 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 16)

ORTHOLOGY for otpa ( Chr: 21 )

CITATIONS (60)

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