ZFIN ID: ZDB-GENE-070119-5
Gene Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
Gene Symbol: obscnb    Nomenclature History

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Previous Names: obscnl, obscurin A (1), si:rp71-18a8.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Involved in myofibril assembly and retina development in camera-type eye. Localizes to M band. Is expressed in central nervous system; heart; retinal neural layer; skeletal muscle; and skeletal muscle cell. Orthologous to human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000022101 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-obscnb N/A 1
MO2-obscnb N/A 3
MO3-obscnb N/A 2
MO4-obscnb N/A 1
DISEASE ASSOCIATED WITH obscnb HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH obscnb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process myofibril assembly (more)
Cellular Component M band (more)
Molecular Function guanyl-nucleotide exchange factor activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA obscnb-201 (1)    Ensembl 4440
obscnb-202 (1)    Ensembl 586
obscnb-203 (1)    Ensembl 3255
obscnb-204 (1)    Ensembl 4979
Browsers: EnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-obscnl polyclonal IgG Rabbit IHC 2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM obscnb No data available
MARKER RELATIONSHIPS
obscnb Contained in: [BAC] RP71-18A8 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
Genomic GenBank:CR792456 (1) 84852 nt
Select Tool
Polypeptide UniProtKB:A0A140LFP0 (1) 1660 aa
Sequence Information (all 6)
ORTHOLOGY for obscnb ( Chr: 24 )
CITATIONS (13)