Gene

hs2st1a

ID
ZDB-GENE-070112-2312
Name
heparan sulfate 2-O-sulfotransferase 1a
Symbol
hs2st1a Nomenclature History
Previous Names
  • hs2st1
  • im:7147474
  • zgc:158230
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Exhibits heparan sulfate sulfotransferase activity. Involved in epiboly involved in gastrulation with mouth forming second; regulation of canonical Wnt signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to Golgi membrane and integral component of membrane. Is expressed in several structures, including brain; immature eye; otic vesicle; pectoral fin; and segmental plate. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Cadwalader et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hs2st1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurofacioskeletal syndrome with or without renal agenesis 619194
Associated With hs2st1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR005331 Sulfotransferase
Family IPR007734 Heparan sulphate 2-O-sulfotransferase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Heparan sulphate 2-O-sulfotransferase P-loop containing nucleoside triphosphate hydrolase Sulfotransferase
UniProtKB:A1L1P8 354
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations