ZFIN ID: ZDB-GENE-070112-2312
Gene Name: heparan sulfate 2-O-sulfotransferase 1a
Gene Symbol: hs2st1a    Nomenclature History

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Previous Names: hs2st1, im:7147474, zgc:158230

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits heparan sulfate sulfotransferase activity. Involved in epiboly involved in gastrulation with mouth forming second; regulation of canonical Wnt signaling pathway; and regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; immature eye; otic vesicle; pectoral fin; and segmental plate. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1).
Genome Resources: Alliance (1),  Gene:791188 (1),  Ensembl(GRCz11):ENSDARG00000099478 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7147474]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11765 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14728 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45098 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hs2st1a N/A 1
    MO2-hs2st1a N/A 1
    DISEASE ASSOCIATED WITH hs2st1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hs2st1a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hs2st1a-201 (1)    Ensembl 3940
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hs2st1a No data available
    MARKER RELATIONSHIPS
    hs2st1a Contained in: [BAC] DKEY-43B14 (1) (order this)
    hs2st1a Encodes: [EST] IMAGE:7147474 (1)
    [cDNA] MGC:158230 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080670 (1) 2025 nt
    Genomic GenBank:BX927330 (1) 203149 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A1L1P8 (1) 354 aa
    Sequence Information (all 11)
    ORTHOLOGY for hs2st1a ( Chr: 2 )
    CITATIONS (20)