Gene

sirt3

ID
ZDB-GENE-070112-1762
Name
sirtuin 3
Symbol
sirt3 Nomenclature History
Previous Names
  • zgc:158774
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable NAD+ binding activity and NAD-dependent histone deacetylase activity. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT3 (sirtuin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Sheng et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sirt3 Human Ortholog
No data available
Associated With sirt3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR026590 Sirtuin family, catalytic core domain
Family IPR003000 Sirtuin family
Family IPR017328 Sirtuin, class I
Homologous_superfamily IPR026591 Sirtuin, catalytic core small domain superfamily
Homologous_superfamily IPR029035 DHS-like NAD/FAD-binding domain superfamily
Domain Details Per Protein
Protein Length DHS-like NAD/FAD-binding domain superfamily Sirtuin, catalytic core small domain superfamily Sirtuin, class I Sirtuin family Sirtuin family, catalytic core domain
UniProtKB:B0S7D4 252
UniProtKB:A0A2R8QMP7 358
UniProtKB:A1L2B7 357
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sirt3 polyclonal IgG Rabbit
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations