ZFIN ID: ZDB-GENE-070112-1762
Gene Name: sirtuin 3
Gene Symbol: sirt3    Nomenclature History

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Previous Name: zgc:158774

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have NAD+ binding activity and NAD-dependent histone deacetylase activity. Predicted to localize to cytoplasm and nucleus. Is expressed in liver and retina. Orthologous to human SIRT3 (sirtuin 3).
Genome Resources: Alliance (1),  Gene:558775 (1),  Ensembl(GRCz11):ENSDARG00000035819 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Sheng et al., 2018
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21101 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sirt3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sirt3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sirt3-201 (1)    Ensembl 1579
    sirt3-203 (1)    Ensembl 1201
    ncRNA sirt3-003 (1)    Ensembl 694
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sirt3 No data available
    MARKER RELATIONSHIPS
    sirt3 Contained in: [BAC] CH211-222K9 (1)
    sirt3 Encodes: [cDNA] MGC:158774 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080174 (1) 1627 nt
    Genomic GenBank:BX663604 (1) 161194 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QMP7 (1) 358 aa
    Sequence Information (all 17)
    ORTHOLOGY for sirt3 ( Chr: 7 )
    CITATIONS (23)