ZFIN ID: ZDB-GENE-070112-1402
Gene Name: mitochondrial antiviral signaling protein
Gene Symbol: mavs    Nomenclature History

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Previous Names: wu:fj20d04, zgc:158392

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in cytoplasmic pattern recognition receptor signaling pathway in response to virus; regulation of transcription, DNA-templated; and response to bacterium. Localizes to mitochondrion. Orthologous to human MAVS (mitochondrial antiviral signaling protein).
Genome Resources: Alliance (1),  Gene:562867 (1),  Ensembl(GRCz11):ENSDARG00000069733 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 6 (144.0h-168.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb338 Small Deletion Unknown Unknown CRISPR
ihb339 Small Deletion Unknown Unknown CRISPR
mk28 Small Deletion Unknown Unknown CRISPR
sa22252 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42165 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mavs 1
    CRISPR2-mavs 1
    MO1-mavs N/A 1
    MO2-mavs N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mavs HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mavs VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mavs-201 (1)    Ensembl 4397
    mavs-203 (1)    Ensembl 790
    mavs-205 (1)    Ensembl 744
    ncRNA mavs-004 (1)    Ensembl 574
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mavs No data available
    MARKER RELATIONSHIPS
    mavs Contained in: [BAC] CH211-1M7 (1)
    mavs Encodes: [EST] fj20d04
    [cDNA] MGC:158392 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080584 (1) 4414 nt
    Genomic GenBank:BX323842 (1) 162929 nt
    Select Tool
    Polypeptide UniProtKB:C7C1L8 (1) 585 aa
    Sequence Information (all 23)
    ORTHOLOGY for mavs ( Chr: 13 )
    CITATIONS (43)