atoh8

ID

ZDB-GENE-061215-7

Name

atonal bHLH transcription factor 8

Symbol

atoh8 Nomenclature History

Previous Names

Zath6 (1)
zgc:158314

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in heart looping and swim bladder formation. Acts upstream of or within heart development; regulation of neural retina development; and regulation of skeletal muscle cell differentiation. Predicted to be located in cytoplasm and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural crest cell; optic cup; optic vesicle; and trunk. Orthologous to human ATOH8 (atonal bHLH transcription factor 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atoh8 Human Ortholog

No data available

Associated With atoh8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR032660	Transcription factor ATOH8, basic helix-loop-helix domain
Family	IPR050359	Basic helix-loop-helix transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily