ZFIN ID: ZDB-GENE-061214-6
Gene Name: forkhead box E3
Gene Symbol: foxe3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in aorta development; lens morphogenesis in camera-type eye; and negative regulation of lens fiber cell differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; cataract 34 multiple types; congenital aphakia; and thoracic aortic aneurysm. Is expressed in several structures, including adenohypophyseal placode; hatching gland; lens; lens placode; and optic primordium. Orthologous to human FOXE3 (forkhead box E3).
Genome Resources: Alliance (1),  Gene:570855 (1),  Ensembl(GRCz11):ENSDARG00000062892 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s4001 Small Deletion Unknown Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-foxe3 1
MO1-foxe3 N/A 1
MO2-foxe3 N/A 1
MO3-foxe3 N/A 2
DISEASE ASSOCIATED WITH foxe3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 34 multiple types Alliance Cataract 34, multiple types 612968
congenital aphakia Alliance Anterior segment dysgenesis 2, multiple subtypes 610256
{Aortic aneurysm, familial thoracic 11, susceptibility to} 617349
DISEASE ASSOCIATED WITH foxe3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process aorta development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001766 Fork head domain
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA foxe3-201 (1)    Ensembl 1652
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-foxe3 polyclonal Rabbit 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM foxe3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(foxe3:vps45-gfp) foxe3 GFPvps45 Danio rerio 1 1
MARKER RELATIONSHIPS
foxe3 Contained in: [BAC] CH73-281K2 (1), CH211-99I20
foxe3 Encodes: [cDNA] MGC:194751 (1), MGC:194769 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001079682 (1) 1663 bp
Genomic GenBank:FP016062 (1) 109334 bp
Select Tool
Polypeptide UniProtKB:A0ES87 (1) 422 aa
Sequence Information (all 14)
ORTHOLOGY for foxe3 ( Chr: 8 )
CITATIONS (30)