Gene

shank2b

ID
ZDB-GENE-061207-58
Name
SH3 and multiple ankyrin repeat domains 2b
Symbol
shank2b Nomenclature History
Previous Names
  • shank2
  • si:dkey-221m4.1
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of synaptic transmission; and regulation of AMPA receptor activity. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shank2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Autism susceptibility 17} 613436
Associated With shank2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR032425 Talin, N-terminal F0 domain
Domain IPR041489 PDZ domain 6
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily PDZ domain PDZ domain 6 PDZ superfamily SH3 domain SH3-like domain superfamily Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Talin, N-terminal F0 domain
UniProtKB:A2AV32 1800
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations