Gene

nod2

ID
ZDB-GENE-061108-4
Name
nucleotide-binding oligomerization domain containing 2
Symbol
nod2 Nomenclature History
Previous Names
  • card15 (1)
  • NLR-A2 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have CARD domain binding activity. Involved in defense response to bacterium; defense response to virus; and regulation of transcription, DNA-templated. Localizes to cytoplasm. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Blau syndrome; autoimmune hypersensitivity disease (multiple); intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nod2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Blau syndrome Alliance Blau syndrome 186580
inflammatory bowel disease 1 Alliance {Inflammatory bowel disease 1, Crohn disease} 266600
{Yao syndrome} 617321
Associated With nod2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001315 CARD domain
Domain IPR007111 NACHT nucleoside triphosphatase
Domain IPR041075 NOD2, winged helix domain
Domain IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length CARD domain Death-like domain superfamily Leucine-rich repeat Leucine-rich repeat domain superfamily NACHT, LRR and PYD domains-containing protein, helical domain HD2 NACHT nucleoside triphosphatase NOD2, winged helix domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q1AMZ9 969
UniProtKB:F8W3K2 980
UniProtKB:T1NXJ6 880
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-nod2 polyclonal Rabbit
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations