ZFIN ID: ZDB-GENE-061108-1
Gene Name: FTO alpha-ketoglutarate dependent dioxygenase
Gene Symbol: fto    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Involved in several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase).
Genome Resources: Alliance (1),  Gene:553363 (1),  Ensembl(GRCz11):ENSDARG00000044216 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
e37 Point Mutation Unknown Premature Stop ENU
sa12749 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fto N/A 1
    MO2-fto N/A 1
    MO3-fto N/A 1
    DISEASE ASSOCIATED WITH fto HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Growth retardation, developmental delay, facial dysmorphism 612938
    {Obesity, susceptibility to, BMIQ14} 612460
    DISEASE ASSOCIATED WITH fto VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Molecular Function oxidative DNA demethylase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fto-201 (1)    Ensembl 851
    fto-202 (1)    Ensembl 3353
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fto monoclonal IgG Mouse WB PhosphoSolutions
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fto No data available
    MARKER RELATIONSHIPS
    fto Contained in: [BAC] CH73-20D12 (1), CH73-34P21 (1), CH73-104M21 (1), CH211-153H7 (1), RP71-23N3 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001345874 (1) 3235 nt
    Genomic GenBank:CT030037 (1) 203577 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8PY24 (1) 580 aa
    Sequence Information (all 29)
    ORTHOLOGY for fto ( Chr: 7 )
    CITATIONS (27)