ZFIN ID: ZDB-GENE-061030-1
Gene Name: cytochrome P450, family 2, subfamily P, polypeptide 8
Gene Symbol: cyp2p8    Nomenclature History

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Previous Names: cyp2j23, si:dkey-183n20.5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in several processes, including exogenous drug catabolic process; organic acid metabolic process; and xenobiotic metabolic process. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2).
Genome Resources: Alliance (1),  Gene:100034366 (1),  Ensembl(GRCz11):ENSDARG00000042982 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37035 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp2p8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp2p8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp2p8-201 (1)    Ensembl 1867
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp2p8 No data available
    MARKER RELATIONSHIPS
    cyp2p8 Contained in: [BAC] DKEY-183N20 (1) (order this)
    cyp2p8 Encodes: [cDNA] MGC:193767 (1), MGC:193769 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083035 (1) 1542 nt
    Genomic GenBank:BX322665 (1) 192437 nt
    Select Tool
    Polypeptide UniProtKB:Q5TZ86 (1) 496 aa
    Sequence Information (all 13)
    ORTHOLOGY for cyp2p8 ( Chr: 20 )
    CITATIONS (26)