Gene
smg1
- ID
- ZDB-GENE-061013-767
- Name
- SMG1 nonsense mediated mRNA decay associated PI3K related kinase
- Symbol
- smg1 Nomenclature History
- Previous Names
-
- zgc:152973
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to act upstream of or within DNA repair and phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR003152 | FATC domain |
| Domain | IPR014009 | PIK-related kinase |
| Domain | IPR035175 | Serine/threonine-protein kinase SMG1, N-terminal |
| Domain | IPR039414 | SMG1, PIKK catalytic domain |
| Family | IPR031559 | Serine/threonine-protein kinase SMG1 |
| Family | IPR050517 | DNA Damage Response and Repair Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | Protein kinase-like domain superfamily | Serine/threonine-protein kinase SMG1 | Serine/threonine-protein kinase SMG1, N-terminal | SMG1, PIKK catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8I7UD82 | InterPro | ||||||||||||
| UniProtKB:F1QLT4 | InterPro | 3635 | |||||||||||
| UniProtKB:C5J7W8 | InterPro | 3640 | |||||||||||
| UniProtKB:A0A2R8QK29 | InterPro | 3644 | |||||||||||
| UniProtKB:A0A8M3AQW2 | InterPro | 3641 | |||||||||||
| UniProtKB:A0A8M3B0Y6 | InterPro | 3640 |
Interactions and Pathways
No data available
Plasmids