ZFIN ID: ZDB-GENE-061009-22
Gene Name: matrix metallopeptidase 16b (membrane-inserted)
Gene Symbol: mmp16b    Nomenclature History

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Previous Name: si:ch211-261f3.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in collagen catabolic process; extracellular matrix organization; and skeletal system development. Predicted to localize to the extracellular space and integral component of plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16).
Genome Resources: Alliance (1),  Gene:572034 (1),  Ensembl(GRCz11):ENSDARG00000058876 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Quick et al., 2012
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a302 Small Deletion Unknown Unknown CRISPR
la014966Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6824 Point Mutation Unknown Premature Stop ENU
    sa31251 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mmp16b 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mmp16b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mmp16b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
    Conserved_site IPR018486 Hemopexin, conserved site
    Domain IPR000585 Hemopexin-like domain
    Domain IPR001818 Peptidase M10, metallopeptidase
    Domain IPR002477 Peptidoglycan binding-like
    Domain IPR006026 Peptidase, metallopeptidase
    Domain IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
    Domain IPR033739 Peptidase M10A, catalytic domain
    Family IPR021190 Peptidase M10A
    Family IPR028697 Matrix metalloproteinase-16
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Homologous_superfamily IPR036365 PGBD-like superfamily
    Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
    Repeat IPR018487 Hemopexin-like repeats
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp16b-202 (1)    Ensembl 3087
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp16b No data available
    MARKER RELATIONSHIPS
    mmp16b Contained in: [BAC] CH211-261F3 (1), DKEY-283M16 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009296801 (1)
    Genomic GenBank:BX928742 (1) 144719 nt
    Select Tool
    Polypeptide UniProtKB:F1R8N4 (1) 618 aa
    Sequence Information (all 10)
    ORTHOLOGY for mmp16b ( Chr: 2 )
    CITATIONS (24)