ZFIN ID: ZDB-GENE-060929-974
Gene Name: cyclin-dependent kinase 4
Gene Symbol: cdk4    Nomenclature History

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Previous Name: zgc:153726

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to localize to nucleus. Is expressed in oocyte stage I and ovary. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma multiforme; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4).
Genome Resources: Alliance (1),  Gene:777730 (1),  Ensembl(GRCz11):ENSDARG00000087937 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41744 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • umb8 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdk4 2
    PHENOTYPE
    Data: Fig. 6 from Webster et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH cdk4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Melanoma, cutaneous malignant, 3} 609048
    DISEASE ASSOCIATED WITH cdk4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component mediator complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdk4-002 (1) 3239
    cdk4-201 (1)    Ensembl 2925
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdk4 No data available
    MARKER RELATIONSHIPS
    cdk4 Contained in: [Fosmid] CH1073-79I11 (1)
    cdk4 Encodes: [cDNA] MGC:153726 (1), MGC:191419 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077777 (1) 1276 nt
    Genomic GenBank:CU633839 (1) 20712 nt
    Polypeptide UniProtKB:F1RDQ7 (1) 297 aa
    Sequence Information (all 15)
    ORTHOLOGY for cdk4 ( Chr: 11 )
    CITATIONS (27)