ZFIN ID: ZDB-GENE-060929-918
Gene Name: TSEN2 tRNA splicing endonuclease subunit
Gene Symbol: tsen2    Nomenclature History

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Previous Name: zgc:154067

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to localize to tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2).
Genome Resources: Alliance (1),  Gene:767713 (1),  Ensembl(GRCz11):ENSDARG00000091851 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41748 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tsen2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 2B Alliance Pontocerebellar hypoplasia type 2B 612389
    DISEASE ASSOCIATED WITH tsen2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process tRNA processing (more)
    Cellular Component nucleus (more)
    Molecular Function lyase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tsen2-201 (1)    Ensembl 769
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tsen2 No data available
    MARKER RELATIONSHIPS
    tsen2 Encodes: [cDNA] MGC:154067 (1), MGC:174217 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001076651 (1) 1577 nt
    Genomic GenBank:CABZ01008489 (1) 4893 nt
    Polypeptide UniProtKB:A8E5A8 (1) 438 aa
    Sequence Information (all 18)
    ORTHOLOGY for tsen2 ( Chr: 11 )
    CITATIONS (17)